RGD Reference Report - [The significance and expression of vascular endothelial growth factor on nasal inverted papillomas]. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

[The significance and expression of vascular endothelial growth factor on nasal inverted papillomas].

Authors: Han, F J  Wang, Y P  Yang, J H  Guan, G M  Dong, Z  Yang, Z Q 
Citation: Han FJ, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2000 Feb;14(2):65-7.
RGD ID: 8551779
Pubmed: PMID:12541477   (View Abstract at PubMed)


OBJECTIVE: To determine the expression of vascular endothelial growth factor (VEGF) and its receptor in nasal inverted papillomas (NIP) and to clarify the function of VEGF in the establishment of NIPs.
METHOD: VEGF and its receptor, fetal liver kinase-1 (flk-1) expression were examined by immunohistochemistry using SP method in sections of NIPs from 11 patients and inferior turbinates from 6 patients with chronic simple rhinitis. An automatic image analyzer was used to detect the staining results. Gray scale, a half-quantitative parameter, was used to describe the expression of VEGF and flk-1.
RESULT: It showed that all the epithelium in NIPs, together with vascular and stroma adjacent to the epithelium, expressed different degree of VEGF. The VEGF expression in epithelium was significantly stronger in NIPs than that in inferior turbinates (P < 0.001). The expressions of both VEGF and flk-1 in vascular endothelium were more intense in NIPs than that in inferior turbinates (P < 0.001, P < 0.001). Flk-1 positive expression was observed in epithelium of NIPs but not in inferior turbinates.
CONCLUSION: The results suggest that VEGF participate in the growth of NIPs, part of which shows the characteristics of containing plenty of blood vessels and being bloody in operation. The enhanced expression of VEGF may also play a key role in the development of edematous stroma. The expression degree of VEGF in the epithelium may be identified as one of the parameters of judging the propensity of NIPs' malignant transformation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
KDRHumaninverted papilloma  IEP protein:increased expression:inferior nasal concha:RGD 
KdrRatinverted papilloma  ISOKDR (Homo sapiens)protein:increased expression:inferior nasal concha:RGD 
KdrMouseinverted papilloma  ISOKDR (Homo sapiens)protein:increased expression:inferior nasal concha:RGD 
VEGFAHumaninverted papilloma  IEP protein:increased expression:inferior nasal concha:RGD 
VegfaRatinverted papilloma  ISOVEGFA (Homo sapiens)protein:increased expression:inferior nasal concha:RGD 
VegfaMouseinverted papilloma  ISOVEGFA (Homo sapiens)protein:increased expression:inferior nasal concha:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kdr  (kinase insert domain receptor)
Vegfa  (vascular endothelial growth factor A)

Genes (Mus musculus)
Kdr  (kinase insert domain protein receptor)
Vegfa  (vascular endothelial growth factor A)

Genes (Homo sapiens)
KDR  (kinase insert domain receptor)
VEGFA  (vascular endothelial growth factor A)


Additional Information