RGD Reference Report - Monocyte chemoattractant protein-1 -2518 A/G single nucleotide polymorphism in Chinese Han patients with ocular Behcet's disease. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Monocyte chemoattractant protein-1 -2518 A/G single nucleotide polymorphism in Chinese Han patients with ocular Behcet's disease.

Authors: Hou, S  Yang, P  Du, L  Jiang, Z  Mao, L  Shu, Q  Zhou, H  Kijlstra, A 
Citation: Hou S, etal., Hum Immunol. 2010 Jan;71(1):79-82. doi: 10.1016/j.humimm.2009.09.354. Epub .
RGD ID: 8548882
Pubmed: PMID:19782713   (View Abstract at PubMed)
DOI: DOI:10.1016/j.humimm.2009.09.354   (Journal Full-text)

Recent studies in Caucasian uveitis patients have shown an association with the -2518 A/G polymorphism of the monocyte chemoattractant protein (MCP)-1 gene. It is unknown whether this polymorphism is also associated with ocular Behcet's disease (BD) in Chinese populations. The aim of the current study was therefore to investigate the possible involvement of MCP-1 in the susceptibility to ocular BD in Chinese Han individuals. A case control association study was performed in 296 ocular BD patients and 319 geographically and age-matched healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Binary logistic regression analysis revealed a decreased frequency of the homozygous AA genotype and an increased frequency of AG genotype of the MCP-1 -2518 polymorphism in ocular BD patients compared with healthy controls, when adjusted for gender (p = 0.048, p = 0.028, respectively). However, when segregated on the basis of several clinical findings, no any association was found between this polymorphism and ocular BD. In conclusion, the present study suggests that the MCP-1 -2518 AA genotype seems to display a protective association with ocular BD, whereas the -2518 AG genotype might be a susceptible factor for ocular BD in the Chinese Han population.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Behcet's disease susceptibilityIAGP 8548882DNA:snp:promoter:g.-2518A>G (human)RGD 
Behcet's disease susceptibilityISOCCL2 (Homo sapiens)8548882; 8548882DNA:snp:promoter:g.-2518A>G (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Genital ulcers susceptibilityIAGP 8548882DNA:snp:promoter:g.-2518A>GRGD 
Oral ulcer susceptibilityIAGP 8548882DNA:snp:promoter:g.-2518A>GRGD 
Uveitis susceptibilityIAGP 8548882DNA:snp:promoter:g.-2518A>GRGD 
Objects Annotated

Genes (Rattus norvegicus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Mus musculus)
Ccl2  (C-C motif chemokine ligand 2)

Genes (Homo sapiens)
CCL2  (C-C motif chemokine ligand 2)

Objects referenced in this article
Gene CCL13 C-C motif chemokine ligand 13 Homo sapiens

Additional Information