RGD Reference Report - [Expression and significances of FSCN1 and HGF in nasal inverted papilloma]. - Rat Genome Database

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[Expression and significances of FSCN1 and HGF in nasal inverted papilloma].

Authors: Yuan, Linlin  Lou, Weihua  Sang, Jianzhong 
Citation: Yuan L, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Apr;26(8):339-42.
RGD ID: 8548614
Pubmed: PMID:22730814   (View Abstract at PubMed)


OBJECTIVE: To study the expressions of FSCN1 and HGF in nasal inverted papilloma (NIP) and explore their role in occurrence and development of this disease.
METHOD: Immunohistochemical method was used to determine the expression of FSCN1 and HGF in 12 cases of chronic hypertrophic rhinitis, 40 cases of NIP and 14 cases of NIP with malignant transformation.
RESULT: FSCN1 was expressed in 52.5% of NIP, 78.6% of NIP with malignant transformation and 8.3% of inferior turbinate of chronic hypertrophic rhinitis. Expression of FSCN1 was significantly higher in NIP and NIP with malignant transformation than in inferior turbinate (P<0.05). HGF was expressed in 85.7% of NIP with malignant transformation and 8.3% of inferior turbinate. Expression of HGF was significantly higher in NIP with malignant transformation than in inferior turbinate (P<0.05). HGF was expressed in 40.0% of NIP,which was higher than that of inferior turbinate. Expression of HGF was positively related to expression of FSCN1 in NIP and NIP with malignant transformation.
CONCLUSION: The abnormal expression of FSCN1 and HGF may be closely correlated with NIP and its malignant process. Analysis of FSCN1 and HGF expression in NIP may be useful in predicting malignant transformation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HGFHumaninverted papilloma  IEP protein:increased expression:inferior nasal concha:RGD 
HgfRatinverted papilloma  ISOHGF (Homo sapiens)protein:increased expression:inferior nasal concha:RGD 
HgfMouseinverted papilloma  ISOHGF (Homo sapiens)protein:increased expression:inferior nasal concha:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hgf  (hepatocyte growth factor)

Genes (Mus musculus)
Hgf  (hepatocyte growth factor)

Genes (Homo sapiens)
HGF  (hepatocyte growth factor)


Additional Information