RGD Reference Report - Intercellular adhesion molecule-1 is required for the early formation of granulomas and participates in the resistance of mice to the infection with the fungus Paracoccidioides brasiliensis.

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Intercellular adhesion molecule-1 is required for the early formation of granulomas and participates in the resistance of mice to the infection with the fungus Paracoccidioides brasiliensis.
Authors:	Moreira, AP Campanelli, AP Cavassani, KA Souto, JT Ferreira, BR Martinez, R Rossi, MA Silva, JS
Citation:	Moreira AP, etal., Am J Pathol. 2006 Oct;169(4):1270-81.
RGD ID:	8547589
Pubmed:	PMID:17003484 (View Abstract at PubMed)
PMCID:	PMC1698859 (View Article at PubMed Central)
DOI:	DOI:10.2353/ajpath.2006.060271 (Journal Full-text)
The migration of leukocytes to inflammatory sites elicited by Paracoccidioides brasiliensis is supposed to be coordinated by cytokines and chemokines. Here, we investigated the role of intercellular adhesion molecule-1 (ICAM-1) in recruiting inflammatory cells to lungs of mice infected with P. brasiliensis and in determining the outcome of the disease. Expression of ICAM-1 was up-regulated on T lymphocytes after infection with the fungus, and its expression was dependent on interferon-gamma, tumor necrosis factor-alpha, and interleukin-12. Moreover, the absence of ICAM-1 resulted in high susceptibility to the infection and delayed formation of granulomatous lesions. In addition, the absence of ICAM-1 resulted in increased growth and dissemination of fungus, decreased number of CD3+CD4+ and CD3+CD8+ T cells, and increased production of interleukin-4 in the inflammatory site. The organization of a granulomatous reaction in mice deficient of ICAM-1 was delayed, starting only on day 60 after infection, whereas in wild-type mice it was complete on day 30 of infection. These data show that ICAM-1 is effectively involved in cellular migration and in the organization of the granulomatous lesion caused by the fungus P. brasiliensis.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
ICAM1	Human	paracoccidioidomycosis		ISO	Icam1 (Mus musculus)		RGD
Icam1	Rat	paracoccidioidomycosis		ISO	Icam1 (Mus musculus)		RGD
Icam1	Mouse	paracoccidioidomycosis		IMP			RGD

Objects Annotated

Genes (Rattus norvegicus)

Icam1 (intercellular adhesion molecule 1)

Genes (Mus musculus)

Icam1 (intercellular adhesion molecule 1)

Genes (Homo sapiens)

ICAM1 (intercellular adhesion molecule 1)

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Intercellular adhesion molecule-1 is required for the early formation of granulomas and participates in the resistance of mice to the infection with the fungus Paracoccidioides brasiliensis.