RGD Reference Report - Intercellular adhesion molecule-1 gene polymorphisms in Behcet's disease. - Rat Genome Database

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Intercellular adhesion molecule-1 gene polymorphisms in Behcet's disease.

Authors: Verity, DH  Vaughan, RW  Kondeatis, E  Madanat, W  Zureikat, H  Fayyad, F  Marr, JE  Kanawati, CA  Wallace, GR  Stanford, MR 
Citation: Verity DH, etal., Eur J Immunogenet. 2000 Apr;27(2):73-6.
RGD ID: 8158123
Pubmed: PMID:10792421   (View Abstract at PubMed)

Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms have been implicated in the susceptibility to inflammatory diseases, including multiple sclerosis and inflammatory bowel disease. The expression of both soluble and tissue ICAM-1 is increased in Behcet's disease (BD) but the contribution of ICAM-1 gene polymorphisms to this disease remains unknown. Associations with BD have been reported for genes within the MHC, including HLA-B51, TNF and MICA, but the role of non-MHC genes in BD remains largely unexplored. We have investigated the frequency of the R/G 241 and K/E 469 ICAM-1 gene polymorphisms in 83 patients with BD disease and 103 healthy controls, all of Palestinian and Jordanian descent, and demonstrated an association between BD and the ICAM-1 E469 allele (Pc = 0.046, OR = 2.1). Among patients, no association was found between the presence of ocular disease and ICAM-1 polymorphisms. While the functional correlate of this polymorphism remains unclear, this finding indicates that a genetic polymorphism in the ICAM-1 gene domain, which is independent of the MHC, may contribute to disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Behcet's disease no_associationIAGP 8158123DNA:SNP:exon:p.R241G (human)RGD 
Behcet's disease no_associationISOICAM1 (Homo sapiens)8158123; 8158123DNA:SNP:exon:p.R241G (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Icam1  (intercellular adhesion molecule 1)

Genes (Mus musculus)
Icam1  (intercellular adhesion molecule 1)

Genes (Homo sapiens)
ICAM1  (intercellular adhesion molecule 1)

Additional Information