RGD Reference Report - The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. - Rat Genome Database

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The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness.

Authors: Saint Andre, AV  Blackwell, NM  Hall, LR  Hoerauf, A  Brattig, NW  Volkmann, L  Taylor, MJ  Ford, L  Hise, AG  Lass, JH  Diaconu, E  Pearlman, E 
Citation: Saint Andre Av, etal., Science. 2002 Mar 8;295(5561):1892-5.
RGD ID: 7794682
Pubmed: PMID:11884755   (View Abstract at PubMed)
DOI: DOI:10.1126/science.1068732   (Journal Full-text)

Parasitic filarial nematodes infect more than 200 million individuals worldwide, causing debilitating inflammatory diseases such as river blindness and lymphatic filariasis. Using a murine model for river blindness in which soluble extracts of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inflammatory response in the cornea was due to species of endosymbiotic Wolbachia bacteria. In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TLR4HumanOcular Onchocerciasis  ISOTlr4 (Mus musculus) RGD 
Tlr4RatOcular Onchocerciasis  ISOTlr4 (Mus musculus) RGD 
Tlr4MouseOcular Onchocerciasis  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr4  (toll-like receptor 4)

Genes (Mus musculus)
Tlr4  (toll-like receptor 4)

Genes (Homo sapiens)
TLR4  (toll like receptor 4)


Additional Information