RGD Reference Report - Cytokine and chemokine expression in the skin from patients with maculopapular exanthema to drugs. - Rat Genome Database

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Cytokine and chemokine expression in the skin from patients with maculopapular exanthema to drugs.

Authors: Fernandez, TD  Mayorga, C  Torres, MJ  Cornejo-Garcia, JA  Lopez, S  Chaves, P  Rondon, C  Blanca, M 
Citation: Fernandez TD, etal., Allergy. 2008 Jun;63(6):712-9. doi: 10.1111/j.1398-9995.2007.01607.x. Epub 2008 Mar 29.
RGD ID: 7483602
Pubmed: PMID:18384452   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1398-9995.2007.01607.x   (Journal Full-text)

BACKGROUND: Maculopapular exanthema (MPE) is the most frequent clinical manifestation of nonimmediate allergic reactions to drugs and T helper 1 (Th1) cytokines and CD4(+) T cells have been shown to play an important role in its pathogenesis. We assessed the role of cytokines and chemokines and their receptors in the pathogenesis of MPE. METHODS: We evaluated skin biopsies and peripheral CD4(+) and CD8(+) T cells from 27 patients during the acute phase of the reaction and 26 exposed controls. Semiquantitative real-time PCR was performed to determine the expression of cytokines and chemokines and their receptors and immunohistochemistry was used to determine the same chemokines and their receptor proteins in skin. RESULTS: There was a high expression of the Th1 cytokines interferon-gamma (P = 0.006) and tumor necrosis factor-alpha (P = 0.022) in skin and CD4(+) T cells (P = 0.007 and P = 0.005, respectively); and of the Th1 chemokines CXCL9 (P = 0.005) and CXCL10 (P = 0.028) in the skin, while their receptor CXCR3 was increased in skin (P = 0.006) and CD4(+) T cells (P = 0.03). Homing chemokine receptors were also increased: CCR6 in skin (P = 0.026) and CD4(+) T cells (P = 0.016), and CCR10 only in CD4(+) T cells (P = 0.016), as well as their ligands, CCL20 and CCL27, in skin alone. Immunohistochemistry confirmed these results. CONCLUSIONS: These data show significant differences in the expression of chemokines and chemokine receptors, related with a Th1 profile, in both skin biopsies and peripheral CD4(+) T cells in patients with drug-induced MPE.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL20Humanexanthem  IEP mRNA and protein:increased expression:skinRGD 
CCR6Humanexanthem  IEP mRNA and protein:increased expression:skinRGD 
Ccl20Ratexanthem  ISOCCL20 (Homo sapiens)mRNA and protein:increased expression:skinRGD 
Ccl20Mouseexanthem  ISOCCL20 (Homo sapiens)mRNA and protein:increased expression:skinRGD 
Ccr6Ratexanthem  ISOCCR6 (Homo sapiens)mRNA and protein:increased expression:skinRGD 
Ccr6Mouseexanthem  ISOCCR6 (Homo sapiens)mRNA and protein:increased expression:skinRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl20  (C-C motif chemokine ligand 20)
Ccr6  (C-C motif chemokine receptor 6)

Genes (Mus musculus)
Ccl20  (C-C motif chemokine ligand 20)
Ccr6  (C-C motif chemokine receptor 6)

Genes (Homo sapiens)
CCL20  (C-C motif chemokine ligand 20)
CCR6  (C-C motif chemokine receptor 6)


Additional Information