RGD Reference Report - Up-regulation of CC chemokine ligand 20 and its receptor CCR6 in the lesional skin of early systemic sclerosis. - Rat Genome Database

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Up-regulation of CC chemokine ligand 20 and its receptor CCR6 in the lesional skin of early systemic sclerosis.

Authors: Tao, J  Li, L  Tan, Z  Li, Y  Yang, J  Tian, F  Wang, L  Ren, Y  Xu, G  He, X  Shen, G  Tu, Y 
Citation: Tao J, etal., Eur J Dermatol. 2011 Sep-Oct;21(5):731-6. doi: 10.1684/ejd.2011.1469.
RGD ID: 7483587
Pubmed: PMID:21742595   (View Abstract at PubMed)
DOI: DOI:10.1684/ejd.2011.1469   (Journal Full-text)

Mononuclear cell (MNC) infiltrate is one of the earliest pathological changes in systemic sclerosis (SSc) skin. However, little is known about the recruitment of these cells into skin lesions. Recently, the role of chemokines has been suggested in the pathogenesis of SSc. Here we studied the expressions and distributions of CC chemokine CCL20 and its receptor CCR6 in early SSc skin lesions and the difference in CCL20 expressions and ability to recruite MNCs of normal dermal fibroblast (NDF) and scleroderma dermal fibroblast (SSDF). We found that the expressions of CCL20 and its receptor CCR6 were obviously up-regulated in SSc in contrast to normal human skin. mRNA levels were significantly expressed in SSc lesional skins vs normal skin tissues. SSDF displayed increased constitutive expressions of CCL20 mRNA and protein. In addition, Th1 cytokines (TNF-alpha and IL-1beta) remarkably increased the expression of CCL20 in both NDF and SSDF in a dose- and time-dependent manner. Supernatants from SSDF showed stronger chemotactic activity to PBMCs than those from NDF. Thus our findings suggest that CCL20 released from cytokine-activated SSDF plays an important role in the induction of SSc by further recruiting more MNCs to the skin.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL20Humansystemic scleroderma  IEP mRNA:increased expression:skinRGD 
CCR6Humansystemic scleroderma  IEP mRNA:increased expression:skinRGD 
Ccl20Ratsystemic scleroderma  ISOCCL20 (Homo sapiens)mRNA:increased expression:skinRGD 
Ccl20Mousesystemic scleroderma  ISOCCL20 (Homo sapiens)mRNA:increased expression:skinRGD 
Ccr6Ratsystemic scleroderma  ISOCCR6 (Homo sapiens)mRNA:increased expression:skinRGD 
Ccr6Mousesystemic scleroderma  ISOCCR6 (Homo sapiens)mRNA:increased expression:skinRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl20  (C-C motif chemokine ligand 20)
Ccr6  (C-C motif chemokine receptor 6)

Genes (Mus musculus)
Ccl20  (C-C motif chemokine ligand 20)
Ccr6  (C-C motif chemokine receptor 6)

Genes (Homo sapiens)
CCL20  (C-C motif chemokine ligand 20)
CCR6  (C-C motif chemokine receptor 6)


Additional Information