RGD Reference Report - QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population. - Rat Genome Database

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QTLs influencing carbohydrate and fat choice in a LOU/CxFischer 344 F2 rat population.

Authors: Marissal-Arvy, N  Diane, A  Moisan, MP  Larue-Achagiotis, C  Tridon, C  Tome, D  Fromentin, G  Mormede, P 
Citation: Marissal-Arvy N, etal., Obesity (Silver Spring). 2013 Apr 17. doi: 10.1002/oby.20485.
RGD ID: 7401255
Pubmed: PMID:23596094   (View Abstract at PubMed)
DOI: DOI:10.1002/oby.20485   (Journal Full-text)

OBJECTIVE: Individual differences in macronutrient selection, particularly fat and carbohydrate, and associated body weight gain are partly inherited as polygenic traits, but the potential genetic pathways are unknown. To give an overview of the Quantitative Trait Loci (QTLs) and candidate gene pathways influencing these differences in rat was aimed in this study. DESIGN AND METHODS: To that end, F2 rats obtained from the crossbreeding between LOU/C and Fischer 344 rat strains to diet self-selection during 3 weeks were submitted. A genome scan was conducted with microsatellite markers covering evenly the whole genome. Genotypes and phenotypes were analyzed separately in male and female F2 rats by multiple interval mapping. Then, lists of candidate genes were treated by the Ingenuity(R) Pathway software to propose gene pathways involved in our phenotypes. RESULTS: Among numerous others, a QTL on chromosome 12 that influences body weight gain, and fat and carbohydrate choices in the LOU/C x Fischer 344 F2 rat population was found. This locus contains notably the acyl-co-A dehydrogenase gene. CONCLUSION: A strong genetic determinism and complex pathways involving numerous candidate genes and processes, notably in accordance with the metabolic theory of feeding behavior control were found.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

QTLs
Bw127  (Body weight QTL 127)
Bw128  (Body weight QTL 128)
Bw129  (Body weight QTL 129)
Bw130  (Body weight QTL 130)
Bw131  (Body weight QTL 131)
Bw132  (Body weight QTL 132)
Bw133  (Body weight QTL 133)
Bw134  (Body weight QTL 134)
Bw135  (Body weight QTL 135)
Bw136  (Body weight QTL 136)
Bw137  (Body weight QTL 137)
Bw138  (Body weight QTL 138)
Bw139  (Body weight QTL 139)
Bw140  (Body weight QTL 140)
Bw141  (Body weight QTL 141)
Bw142  (Body weight QTL 142)
Foco10  (Food consumption QTL 10)
Foco11  (Food consumption QTL 11)
Foco12  (Food consumption QTL 12)
Foco13  (Food consumption QTL 13)
Foco14  (Food consumption QTL 14)
Foco15  (Food consumption QTL 15)
Foco16  (Food consumption QTL 16)
Foco17  (Food consumption QTL 17)
Foco18  (Food consumption QTL 18)
Foco19  (Food consumption QTL 19)
Foco20  (Food consumption QTL 20)
Foco21  (Food consumption QTL 21)
Foco22  (Food consumption QTL 22)
Foco23  (Food consumption QTL 23)
Foco24  (Food consumption QTL 24)
Foco25  (Food consumption QTL 25)
Foco26  (Food consumption QTL 26)
Foco27  (Food consumption QTL 27)
Foco28  (Food consumption QTL 28)
Foco29  (Food consumption QTL 29)
Foco3  (Food consumption QTL 3)
Foco30  (Food consumption QTL 30)
Foco31  (Food consumption QTL 31)
Foco32  (Food consumption QTL 32)
Foco4  (Food consumption QTL 4)
Foco5  (Food consumption QTL 5)
Foco6  (Food consumption QTL 6)
Foco7  (Food consumption QTL 7)
Foco8  (Food consumption QTL 8)
Foco9  (Food consumption QTL 9)

Strains
F344/IcoCrlf  (NA)
LOU/NimrOlaHsd  (Louvain)

Objects referenced in this article
QTL Kcal2_m kilocalorie 2 (mouse) Mus musculus
QTL Alc10 Alcohol consumption QTL 10 Rattus norvegicus
QTL Alc12 Alcohol consumption QTL 12 Rattus norvegicus
QTL Alc5 Alcohol consumption QTL 5 Rattus norvegicus
QTL Alc6 Alcohol consumption QTL 6 Rattus norvegicus
QTL Alc9 Alcohol consumption QTL 9 Rattus norvegicus
QTL Niddm27 Non-insulin dependent diabetes mellitus QTL 27 Rattus norvegicus
QTL Niddm38 Non-insulin dependent diabetes mellitus QTL 38 Rattus norvegicus

Additional Information