RGD Reference Report - Interleukin-1 beta regulation of islet and thyroid autoimmunity in the BB rat. - Rat Genome Database

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Interleukin-1 beta regulation of islet and thyroid autoimmunity in the BB rat.

Authors: Vertrees, S  Wilson, CA  Ubungen, R  Wilson, D  Baskin, DG  Toivola, B  Jacobs, C  Boiani, N  Baker, P  Lernmark, A 
Citation: Vertrees S, etal., J Autoimmun. 1991 Oct;4(5):717-32.
RGD ID: 7401233
Pubmed: PMID:1797022   (View Abstract at PubMed)

Daily injections of high dose human recombinant interleukin-1 beta (IL-1 beta) accelerated the onset of both insulin-dependent diabetes mellitus and lymphocytic thyroiditis in genetically prone BB rats. In diabetes-resistant BB rats, high dose IL-1 beta failed to induce diabetes. Additionally, the presence of neutralizing IL-1 beta antibodies in these rats strongly correlated with inhibition of lymphocytic thyroiditis. Since low dose IL-1 beta protects diabetes-prone rats from IDDM, we conclude that IL-1 beta is a potent modulator of autoimmune diabetes and thyroid disease in genetically susceptible rats.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL1BHumantype 1 diabetes mellitus  IDA  RGD 
Il1bRattype 1 diabetes mellitus  ISOIL1B (Homo sapiens) RGD 
Il1bMousetype 1 diabetes mellitus  ISOIL1B (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)


Additional Information