RGD Reference Report - Presence of tumor necrosis factor alpha and interleukin-6 in renal mesangial cells of lupus nephritis patients. - Rat Genome Database

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Presence of tumor necrosis factor alpha and interleukin-6 in renal mesangial cells of lupus nephritis patients.

Authors: Malide, D  Russo, P  Bendayan, M 
Citation: Malide D, etal., Hum Pathol. 1995 May;26(5):558-64.
RGD ID: 7394786
Pubmed: PMID:7750940   (View Abstract at PubMed)

Tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) antigenic sites were shown within the resident glomerular mesangial cells of lupus nephritis patients applying the colloidal gold immunocytochemical approach at the electron microscopic level. Using specific polyclonal antibodies against human recombinant (hr) TNF alpha and hrIL-6 in conjunction with the protein A-gold complex, TNF alpha and IL-6 were shown in the mesangial cells, being particularly associated with the membranes of the rough endoplasmic reticulum. In addition, IL-6 also was present in glomerular immune deposits and occasionally in glomerular epithelial cells. In normal renal tissue the TNF alpha and IL-6 immunoreactivities were undetectable. The specific presence of TNF alpha and IL-6 in pathological specimens was shown by several control experiments. Thus, our results offered morphological support that TNF alpha and IL-6 might play a role in human lupus nephritis. The data showed their synthesis by the mesangial cells and their possible participation in the progression to chronicity of the renal injury on secretion.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TNFHumancicatricial pemphigoid  IEP protein:increased expression:Conjunctiva:RGD 
TnfRatcicatricial pemphigoid  ISOTNF (Homo sapiens)protein:increased expression:Conjunctiva:RGD 
TnfMousecicatricial pemphigoid  ISOTNF (Homo sapiens)protein:increased expression:Conjunctiva:RGD 
TNFHumanlupus nephritis  IEP protein:increased expression:glomerular mesangial cellRGD 
TnfRatlupus nephritis  ISOTNF (Homo sapiens)protein:increased expression:glomerular mesangial cellRGD 
TnfMouselupus nephritis  ISOTNF (Homo sapiens)protein:increased expression:glomerular mesangial cellRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tnf  (tumor necrosis factor)

Genes (Mus musculus)
Tnf  (tumor necrosis factor)

Genes (Homo sapiens)
TNF  (tumor necrosis factor)


Additional Information