RGD Reference Report - Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. - Rat Genome Database

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Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.

Authors: Zylka, MJ  Dong, X  Southwell, AL  Anderson, DJ 
Citation: Zylka MJ, etal., Proc Natl Acad Sci U S A 2003 Aug 19;100(17):10043-8. Epub 2003 Aug 8.
RGD ID: 737883
Pubmed: PMID:12909716   (View Abstract at PubMed)
PMCID: PMC187757   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.1732949100   (Journal Full-text)

The Mas-related genes (Mrgs) comprise a family of >50 G protein-coupled receptors (GPCRs), many of which are expressed in specific subsets of nociceptive sensory neurons in mice. In contrast, humans contain a related but nonorthologous family of genes, called MrgXs or sensory neuron-specific receptors, of which many fewer appear to be expressed in sensory neurons. To determine whether the diversity of murine Mrgs is generic to rodents or is an atypical feature of mice, we characterized MrgA, MrgB, MrgC, and MrgD subfamilies in rat and gerbil. Surprisingly, although mice have approximately 22 MrgA and approximately 14 MrgC genes, rats and gerbils have just a single MrgA and MrgC gene. This murine-specific expansion likely reflects recent retrotransposon-mediated unequal crossover events. The expression of Mrgs in rat sensory ganglia suggests that the extensive cellular diversity in mice can be simplified to a core subset of approximately four different genes (MrgA, MrgB, MrgC, and MrgD), defining a similar number of neuronal subpopulations. Our results suggest more generally that mouse-human genomic comparisons may sometimes reveal differences atypical of rodents.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Mas1l  (MAS1 proto-oncogene like, G protein-coupled receptor)
Mrgprb13  (MAS-related GPR, member B13)
Mrgprb4  (MAS-related GPR, member B4)
Mrgprb5  (MAS-related G protein-coupled receptor, member B5)
Mrgprd  (MAS related GPR family member D)
Mrgpre  (MAS related GPR family member E)
Mrgprf  (MAS related GPR family member F)
Mrgprg  (MAS related GPR family member G)
Mrgprx1  (MAS related GPR family member X1)
Mrgprx2  (MAS related GPR family member X2)
Mrgprx2l  (MAS-related G protein-coupled receptor, member X2-like)

Objects referenced in this article
Gene MRGPRD MAS related GPR family member D Homo sapiens
Gene Mrgprb4 MAS-related GPR, member B4 Mus musculus
Gene Mrgprb8 MAS-related GPR, member B8 Mus musculus
Gene Mrgprd MAS-related GPR, member D Mus musculus
Gene Mrgpre MAS-related GPR, member E Mus musculus
Gene Mrgprf MAS-related GPR, member F Mus musculus
Gene Mrgprg MAS-related GPR, member G Mus musculus
Gene Mrgprh MAS-related GPR, member H Mus musculus
Gene Mrgprx1 MAS-related GPR, member X1 Mus musculus
Gene Mas1 MAS1 proto-oncogene, G protein-coupled receptor Rattus norvegicus

Additional Information