RGD Reference Report - Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants.

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Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants.
Authors:	Heeley, RP Gill, E Van Zutphen, B Kenyon, CJ Sutcliffe, RG
Citation:	Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
RGD ID:	737877
Pubmed:	PMID:9501302 (View Abstract at PubMed)
The polyglutamine tract, beginning at codon 75 in the N-terminal modulatory domain of rat glucocorticoid receptor (rGR), was analyzed in 61 inbred strains and 155 wild caught Rattus norvegicus. A discontinuous distribution of repeat lengths was found (7, 17-23 repeats). To investigate the possible significance of this distribution, full-length rGR cDNAs with 7, 18, 20, and 21 CAG repeats were expressed in CV-1 cells, and the resulting GR protein analyzed by Western blots and extensive Scatchard analyses. The quantity and steroid binding capacity of GR, together with the binding affinities for dexamethasone and corticosterone, were found to be indistinguishable for the four repeat alleles. From the sequencing of four inbred strains CAG repeat variants were found to be flanked by silent allelic substitutions at nucleotide positions 198, 531, and 711. The four variable sites extended over 471-519 bp of coding sequence, forming six Grl haplotypes. The results are discussed in the light of genetic studies on the Milan hypertensive and normotensive strains of rat. Codon sequence of rat GR required amendment at the following residues: D98, G226, D260, P600, and F602.

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Objects referenced in this article

Strain	A2/Colle	null	Rattus norvegicus
Strain	ACI/Kun	null	Rattus norvegicus
Strain	ACI/SegHsd	null	Rattus norvegicus
Strain	ACI/Ztm	null	Rattus norvegicus
Strain	AGUS/OlaHsd	null	Rattus norvegicus
Strain	ALC/Colle	null	Rattus norvegicus
Strain	AMORAT/Wsl	null	Rattus norvegicus
Strain	AO/OlaHsd	null	Rattus norvegicus
Strain	ARISTORAT/Wsl	null	Rattus norvegicus
Strain	AS/Ztm	null	Rattus norvegicus
Strain	AUG/OlaHsd	null	Rattus norvegicus
Strain	BBWB/Mol	null	Rattus norvegicus
Strain	BDII/Ztm	null	Rattus norvegicus
Strain	BDIV/lfz	null	Rattus norvegicus
Strain	BDX/Cub	null	Rattus norvegicus
Strain	BN/Crl	null	Rattus norvegicus
Strain	BN/Cub	null	Rattus norvegicus
Strain	BN/Gro	null	Rattus norvegicus
Strain	BN/Gut	null	Rattus norvegicus
Strain	BN/Han	null	Rattus norvegicus
Strain	BN/Maas	null	Rattus norvegicus
Strain	BN/Mol	null	Rattus norvegicus
Strain	BN/NHsdCpb	null	Rattus norvegicus
Strain	BN/OlaHsd	null	Rattus norvegicus
Strain	BN/Orl	null	Rattus norvegicus
Strain	BN/RijKun	null	Rattus norvegicus
Strain	BN/RijN	null	Rattus norvegicus
Strain	BN/SsN	null	Rattus norvegicus
Strain	BP/Cub	null	Rattus norvegicus
Strain	BS/Ztm	null	Rattus norvegicus
Strain	BUF/Ztm	null	Rattus norvegicus
Strain	CAP/Kuv	null	Rattus norvegicus
Strain	COP/OlaHsd	null	Rattus norvegicus
Strain	DA/Ztm	null	Rattus norvegicus
Strain	DZB/Gro	null	Rattus norvegicus
Strain	E3/Ztm	null	Rattus norvegicus
Strain	F344/Ztm	null	Rattus norvegicus
Strain	GC/Kun	null	Rattus norvegicus
Strain	LE/Ztm	null	Rattus norvegicus
Strain	LEP/Cub	null	Rattus norvegicus
Strain	LEW/Cub	null	Rattus norvegicus
Strain	LEW/Gut	null	Rattus norvegicus
Strain	LEW/Han	null	Rattus norvegicus
Strain	LEW/Ipcv	null	Rattus norvegicus
Strain	LEW/Kuv	null	Rattus norvegicus
Strain	LEW/Maas	null	Rattus norvegicus
Strain	LEW/Nhg	null	Rattus norvegicus
Strain	LEW/NHsdCpb	null	Rattus norvegicus
Strain	LEW/Orl	null	Rattus norvegicus
Strain	LEW/SsNHsd	null	Rattus norvegicus
Strain	LEW/Ztm	LEW/Ztm	Rattus norvegicus
Strain	LH/Ztu	null	Rattus norvegicus
Strain	LOU/CHan	Louvain	Rattus norvegicus
Strain	MNS/Gib	Milan Normotensive Strain	Rattus norvegicus
Strain	MWF/Hsd	Munich Wistar Fromter	Rattus norvegicus
Strain	NAR/SaU	non-albumin rat	Rattus norvegicus
Strain	OM/Ztm	Osborne-Mendel	Rattus norvegicus
Strain	PAR/Wsl	null	Rattus norvegicus
Strain	PVG/OlaHsd	null	Rattus norvegicus
Strain	R/A	null	Rattus norvegicus
Strain	R/AEurRij	null	Rattus norvegicus
Strain	R/AWa	null	Rattus norvegicus
Strain	SD/Rij	null	Rattus norvegicus
Strain	SDL/Ipcv	null	Rattus norvegicus
Strain	SPRD/Ztm	null	Rattus norvegicus
Strain	SR/JrIpcv	null	Rattus norvegicus
Strain	SR/JrMol	null	Rattus norvegicus
Strain	SS/JrIpcv	null	Rattus norvegicus
Strain	U/A	null	Rattus norvegicus
Strain	WF/Gut	null	Rattus norvegicus
Strain	WF/Mol	null	Rattus norvegicus
Strain	WF/NHsd	null	Rattus norvegicus
Strain	WF/Ztm	null	Rattus norvegicus
Strain	WIST/Nhg	Wistar	Rattus norvegicus
Strain	WKY/Ztm	null	Rattus norvegicus
Strain	WOKA/K	null	Rattus norvegicus

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Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants.