RGD Reference Report - Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. - Rat Genome Database

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Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice.

Authors: Offermanns, S  Zhao, LP  Gohla, A  Sarosi, I  Simon, MI  Wilkie, TM 
Citation: Offermanns S, etal., EMBO J 1998 Aug 3;17(15):4304-12.
RGD ID: 737757
Pubmed: PMID:9687499   (View Abstract at PubMed)
PMCID: PMC1170764   (View Article at PubMed Central)
DOI: DOI:10.1093/emboj/17.15.4304   (Journal Full-text)

Heterotrimeric G proteins of the Gq class have been implicated in signaling pathways regulating cardiac growth under physiological and pathological conditions. Knockout mice carrying inactivating mutations in both of the widely expressed G alpha q class genes, G alpha q and G alpha 11, demonstrate that at least two active alleles of these genes are required for extrauterine life. Mice carrying only one intact allele [G alpha q(-/+);G alpha 11(-/-) or G alpha q(-/-);G alpha 11(-/+)] died shortly after birth. These mutants showed a high incidence of cardiac malformation. In addition, G alpha q(-/-);G alpha 11(-/+) newborns suffered from craniofacial defects. Mice lacking both G alpha q and G alpha 11 [G alpha q(-/-);G alpha 11(-/-)] died at embryonic day 11 due to cardiomyocyte hypoplasia. These data demonstrate overlap in G alpha q and G alpha 11 gene functions and indicate that the Gq class of G proteins plays a crucial role in cardiac growth and development.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Objects Annotated

Genes (Rattus norvegicus)
Gna11  (G protein subunit alpha 11)
Gnaq  (G protein subunit alpha q)

Genes (Mus musculus)
Gna11  (guanine nucleotide binding protein, alpha 11)
Gnaq  (guanine nucleotide binding protein, alpha q polypeptide)

Genes (Homo sapiens)
GNA11  (G protein subunit alpha 11)
GNAQ  (G protein subunit alpha q)

Objects referenced in this article
Gene Gna14 guanine nucleotide binding protein, alpha 14 Mus musculus
Gene Gna15 guanine nucleotide binding protein, alpha 15 Mus musculus

Additional Information