RGD Reference Report - Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. - Rat Genome Database

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Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A.

Authors: Oliver, PM  Fox, JE  Kim, R  Rockman, HA  Kim, HS  Reddick, RL  Pandey, KN  Milgram, SL  Smithies, O  Maeda, N 
Citation: Oliver PM, etal., Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14730-5.
RGD ID: 737701
Pubmed: PMID:9405681   (View Abstract at PubMed)
PMCID: PMC25105   (View Article at PubMed Central)

Natriuretic peptides, produced in the heart, bind to the natriuretic peptide receptor A (NPRA) and cause vasodilation and natriuresis important in the regulation of blood pressure. We here report that mice lacking a functional Npr1 gene coding for NPRA have elevated blood pressures and hearts exhibiting marked hypertrophy with interstitial fibrosis resembling that seen in human hypertensive heart disease. Echocardiographic evaluation of the mice demonstrated a compensated state of systemic hypertension in which cardiac hypertrophy and dilatation are evident but with no reduction in ventricular performance. Nevertheless, sudden death, with morphologic evidence indicative in some animals of congestive heart failure and in others of aortic dissection, occurred in all 15 male mice lacking Npr1 before 6 months of age, and in one of 16 females in our study. Thus complete absence of NPRA causes hypertension in mice and leads to cardiac hypertrophy and, particularly in males, lethal vascular events similar to those seen in untreated human hypertensive patients.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
NPR1HumanAortic Rupture  ISONpr1 (Mus musculus)associated with HypertensionRGD 
Npr1RatAortic Rupture  ISONpr1 (Mus musculus)associated with HypertensionRGD 
Npr1MouseAortic Rupture  IMP associated with HypertensionRGD 
NPR1HumanCardiomegaly  ISONpr1 (Mus musculus)associated with HypertensionRGD 
Npr1RatCardiomegaly  ISONpr1 (Mus musculus)associated with HypertensionRGD 
Npr1MouseCardiomegaly  IMP associated with HypertensionRGD 
NPR1Humancongestive heart failure  ISONpr1 (Mus musculus)associated with HypertensionRGD 
Npr1Ratcongestive heart failure  ISONpr1 (Mus musculus)associated with HypertensionRGD 
Npr1Mousecongestive heart failure  IMP associated with HypertensionRGD 
Npr1RatSudden Death  ISONpr1 (Mus musculus)associated with HypertensionRGD 

Objects Annotated

Genes (Rattus norvegicus)
Npr1  (natriuretic peptide receptor 1)

Genes (Mus musculus)
Npr1  (natriuretic peptide receptor 1)

Genes (Homo sapiens)
NPR1  (natriuretic peptide receptor 1)

Objects referenced in this article
Gene NPR3 natriuretic peptide receptor 3 Homo sapiens
Gene Npr3 natriuretic peptide receptor 3 Rattus norvegicus

Additional Information