RGD Reference Report - Serum leptin concentration is linked to chromosomes 2 and 6 in the OLETF rat, an animal model of type 2 diabetes with mild obesity. - Rat Genome Database

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Serum leptin concentration is linked to chromosomes 2 and 6 in the OLETF rat, an animal model of type 2 diabetes with mild obesity.

Authors: Ogino, T  Moralejo, DH  Kose, H  Yamada, T  Matsumoto, K 
Citation: Ogino T, etal., Mamm Genome 2003 Dec;14(12):839-44.
RGD ID: 737686
Pubmed: PMID:14724732   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-003-2295-7   (Journal Full-text)

Leptin is produced by adipose tissue and acts as a feedback signal to the hypothalamus controlling energy homeostasis, by reducing food consumption and increasing energy expenditure. Because serum leptin levels are highly correlated with body fat mass, they can be used as an index to predict obesity-related diseases. However, the identity of genetic factors that influence the obesity and the obesity-related metabolic disorders remains largely unknown. In this study, we performed a whole-genome scan search, using 382 F2 intercross progeny between the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, an animal model for obese type 2 diabetes in human, and F344 rat, in order to identify loci responsible for the regulation of leptin and other obesity-related plasma substances. We have identified two quantitative trait loci (QTLs) contributing to serum leptin levels. These two loci, designated Olep1 [Chromosome (Chr) 2] and Olep2 (Chr 6), were homologous to those of human genome regions containing several potential candidate genes for obesity. These are fatty acid-binding protein 2 (FABP2), FABP4, and FABP5 for Olep1, and proopiomelanocortin (POMC) and glucose regulatory protein (GCKR) for Olep2.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Scl29RatHypercholesterolemia  IAGP  RGD 
Stl10RatHypertriglyceridemia  IAGP  RGD 
Stl11RatHypertriglyceridemia  IAGP  RGD 
Stl12RatHypertriglyceridemia  IAGP  RGD 
Slep1Ratobesity  IDA  RGD 
Slep2Ratobesity  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype


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Objects Annotated

Genes (Rattus norvegicus)
Fabp4  (fatty acid binding protein 4)

QTLs
Scl29  (Serum cholesterol level QTL 29)
Slep1  (Serum leptin concentration QTL 1)
Slep2  (Serum leptin concentration QTL 2)
Stl10  (Serum triglyceride level QTL 10)
Stl11  (Serum triglyceride level QTL 11)
Stl12  (Serum triglyceride level QTL 12)

Strains
F344/NRrrc  (NA)
OLETF  (Otsuka Long-Evans Tokushima fatty)


Additional Information