RGD Reference Report - Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats. - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Community Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Genes unlinked to the leptin receptor influence urinary albumin excretion in obese Zucker rats.

Authors: Kim, K  Warden, CH  Griffey, SM  Vilches-Moure, JG  Hansen, S  Cuppen, E  Nijman, IJ  Chiu, S  Stern, JS 
Citation: Kim K, etal., Physiol Genomics. 2010 Feb 16.
RGD ID: 7365117
Pubmed: PMID:20159938   (View Abstract at PubMed)
PMCID: PMC2869106   (View Article at PubMed Central)
DOI: DOI:10.1152/physiolgenomics.90367.2008   (Journal Full-text)

We have previously shown that 90% of outbred obese Zucker Lepr(fa/fa) rats die prematurely of renal disease. Thus, renal disease in obese Zucker Lepr(fa/fa) rats may be caused by the LEPR mutation on chromosome 5, by the obesity, or it may be influenced by Zucker susceptibility alleles of genes on other chromosomes. We have searched for susceptibility genes on other chromosomes using urinary albumin excretion (UAE) as an early indicator of altered renal function in a backcross of (Brown Norway x inbred Zucker) F1 x inbred Zucker, which we name the BZZ cross. 237 BZZ backcross animals were sacrificed at 15 weeks of age. All included animals were homozygous for the fatty mutation of LEPR and were obese. Urinary creatinine measurements were used to calculate the Albumin to Creatinine Ratio (ACR). We identified direct effect quantitative trait loci (QTLs) for UAE and ACR on Chromosome 1 (LOD scores = 3.6 and 2.86, respectively) in males, and Chromosome 4 (LOD score = 2.9) in females. Significant QTLs were identified for left kidney weight for females on Chromosomes 3 and 12. We also demonstrated that kidneys from 15 week old obese inbred Zucker rats already show evidence of kidney pathology: tubular dilation, proteinaceous fluid accumulation, evidence for inflammation, and mild mesangial and tubular membrane basement membrane thickening. Both lean Zucker rats and the BN rats showed no evidence for these changes. Thus, by removing the influence of the Lepr(fa/fa) mutation from analysis we have identified UAE QTLs unlinked to LEPR. Key words: urinary albumin excretion, Zucker, kidney, UAE.



Disease Annotations    
Albuminuria  (IAGP)
obesity  (IAGP,ISO)
proteinuria  (IAGP,ISO)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

Genes (Rattus norvegicus)
Lepr  (leptin receptor)
Leprfa  (leptin receptor; fa mutant)

Genes (Mus musculus)
Lepr  (leptin receptor)

Genes (Homo sapiens)
LEPR  (leptin receptor)

QTLs
Bw124  (Body weight QTL 124)
Bw125  (Body weight QTL 125)
Kidm42  (Kidney mass QTL 42)
Stl32  (Serum triglyceride level QTL 32)
Uae40  (Urinary albumin excretion QTL 40)
Uae41  (Urinary albumin excretion QTL 41)
Uae42  (Urinary albumin excretion QTL 42)
Uae43  (Urinary albumin excretion QTL 43)
Uae44  (Urinary albumin excretion QTL 44)
Uae45  (Urinary albumin excretion QTL 45)
Uae46  (Urinary albumin excretion QTL 46)

Strains
BN/Crl  (NA)
ZUC-LeprfaSte-/-  (NA)

Objects referenced in this article
Marker rs8168428 rs8168428 Rattus norvegicus
Marker rs8165230 rs8165230 Rattus norvegicus
Marker rs105610447 rs105610447 Rattus norvegicus
Marker rs8156450 rs8156450 Rattus norvegicus
Marker rs8153618 rs8153618 Rattus norvegicus
Marker rs8158000 rs8158000 Rattus norvegicus
Marker rs8164304 rs8164304 Rattus norvegicus
Marker rs8160961 rs8160961 Rattus norvegicus
Marker rs8152181 rs8152181 Rattus norvegicus
Marker rs8163932 rs8163932 Rattus norvegicus

Additional Information