RGD Reference Report - Human leukocyte antigen serologic and DNA typing of Behcet's disease and its primary association with B51. - Rat Genome Database

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Human leukocyte antigen serologic and DNA typing of Behcet's disease and its primary association with B51.

Authors: Mizuki, N  Inoko, H  Mizuki, N  Tanaka, H  Kera, J  Tsuiji, K  Ohno, S 
Citation: Mizuki N, etal., Invest Ophthalmol Vis Sci. 1992 Nov;33(12):3332-40.
RGD ID: 7365104
Pubmed: PMID:1358857   (View Abstract at PubMed)

Ninety Japanese patients with Behcet's disease (BD) were typed for human leukocyte antigen (HLA)-DRB1, -DQA1-, -DQB1, and -DPB1 alleles by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and for HLA-A, -B, -C, -DR, and -DQ antigens by conventional serologic typing. Serologic HLA typing showed a remarkably significant increase of HLA-B51 and a significant decrease of HLA-DQw1 in the patients with BD, especially those with ocular lesions including complete type, as compared with the control group (for B51, chi-squared = 46.75, P corrected < 0.001, relative risk [RR] = 7.9; for DQw1, chi-squared = 12.10, P corrected < 0.01, RR = 0.4). By PCR-RFLP genotyping, no significant difference was revealed in any class II alleles between the patient and the control groups in the corrected P value test, but P value analysis showed the significantly high frequency of DRB1*0802 and the significantly low frequencies of DQA1*0103, DQB1*0601, and DQB1*0501. No significant difference was observed in any DPB1 alleles by either P value analysis. These results indicated that the primary and primordial gene(s) responsible for the susceptibility to BD, especially related to ocular lesions, were not located in the HLA class II gene region but were in or very close to the HLA-B locus in the class I region. They also suggested the possibility that BD was a symptom complex associated with some independent diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Behcet's disease susceptibilityISOHLA-DRB1 (Homo sapiens)7365104; 7365104DNA:polymorphism: :DRB1*0802(human)RGD 
Behcet's disease susceptibilityIAGP 7365104DNA:polymorphism: :DRB1*0802(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
RT1-Db1  (RT1 class II, locus Db1)

Genes (Mus musculus)
H2-Eb1  (histocompatibility 2, class II antigen E beta)

Genes (Homo sapiens)
HLA-DRB1  (major histocompatibility complex, class II, DR beta 1)

Additional Information