RGD Reference Report - Lack of association of HLA-B*51 with a severe disease course in Behcet's disease. - Rat Genome Database

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Lack of association of HLA-B*51 with a severe disease course in Behcet's disease.

Authors: Gul, A  Uyar, FA  Inanc, M  Ocal, L  Tugal-Tutkun, I  Aral, O  Konice, M  Saruhan-Direskeneli, G 
Citation: Gul A, etal., Rheumatology (Oxford). 2001 Jun;40(6):668-72.
RGD ID: 7364939
Pubmed: PMID:11426025   (View Abstract at PubMed)

OBJECTIVE: To investigate the previously reported association of HLA-B51 with the manifestations and severity of Behcet's disease (BD). METHODS: The study group consisted of 148 consecutive BD patients (89 male, 59 female) with a minimum disease duration of 5 yr followed up at an out-patient BD clinic in a tertiary referral centre. The patients were classified into three severity groups (mild, moderate, severe) using a modified form of the BD total activity index. HLA-B alleles were determined by DNA amplification using the polymerase chain reaction and sequential hybridization with sequence-specific oligonucleotide probes. RESULTS: The frequencies of genital ulceration [odds ratio (OR)=3.1, 95% confidence interval (CI) 1.3-7.5], skin findings (erythema nodosum, folliculitis or acne-like lesions) (OR=4.4, 95% CI 1.1-17.7), a positive skin pathergy test (OR=3.4, 95% CI 1.1-10.9) and eye disease (OR=1.8, 95% CI 0.9-3.7) were all higher in B*51-positive patients. By contrast, no significant association was observed between B*51 positivity and a severe disease course, and B*51 homozygosity did not exhibit a prominent association with the severity of BD. Male sex was found to be the strongest determinant of the severity of BD by logistic regression analysis (OR=4.7, 95% CI 1.9-11.2). CONCLUSION: HLA-B*51 does not exhibit a strong association with a more severe disease course in BD. The involvement of other genetic and/or environmental factors seems to be required and to be more important than B*51 for the progression of BD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Behcet's disease  ISOHLA-B (Homo sapiens)7364939; 7364939DNA:polymorphisms:cds:HLA-B*51 (human and Turkish)RGD 
Behcet's disease no_associationISOHLA-B (Homo sapiens)7364939; 7364939severe disease more ...RGD 
Behcet's disease  IAGP 7364939DNA:polymorphism:cds:HLA-B*51 (human and Turkish)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Genital ulcers  IAGP 7364939DNA:polymorphism:cds:HLA-B*51 (Turkish)RGD 
Inflammatory abnormality of the skin  IAGP 7364939DNA:polymorphism:cds:HLA-B*51 (Turkish)RGD 
Positive pathergy test  IAGP 7364939DNA:polymorphism:cds:HLA-B*51 (Turkish)RGD 
Uveitis  IAGP 7364939DNA:polymorphism:cds:HLA-B*51 (Turkish)RGD 
Objects Annotated

Genes (Rattus norvegicus)
RT1-CE13  (RT1 class I, locus CE13)
RT1-M5  (RT1 class Ib, locus M5)

Genes (Mus musculus)
H2-M5  (histocompatibility 2, M region locus 5)
H2-Q4  (histocompatibility 2, Q region locus 4)

Genes (Homo sapiens)
HLA-B  (major histocompatibility complex, class I, B)

Additional Information