RGD Reference Report - Complexins regulate a late step in Ca2+-dependent neurotransmitter release. - Rat Genome Database

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Complexins regulate a late step in Ca2+-dependent neurotransmitter release.

Authors: Reim, K  Mansour, M  Varoqueaux, F  McMahon, HT  Sudhof, TC  Brose, N  Rosenmund, C 
Citation: Reim K, etal., Cell 2001 Jan 12;104(1):71-81.
RGD ID: 734813
Pubmed: PMID:11163241   (View Abstract at PubMed)

Synaptic vesicle fusion at synapses is triggered by increases in cytosolic Ca2+ levels. However, the identity of the Ca2+ sensor and the transduction mechanism of the Ca2+ trigger are unknown. We show that Complexins, stoichiometric components of the exocytotic core complex, are important regulators of transmitter release at a step immediately preceding vesicle fusion. Neurons lacking Complexins show a dramatically reduced transmitter release efficiency due to decreased Ca2+ sensitivity of the synaptic secretion process. Analyses of mutant neurons demonstrate that Complexins are acting at or following the Ca2+-triggering step of fast synchronous transmitter release by regulating the exocytotic Ca2+ sensor, its interaction with the core complex fusion machinery, or the efficiency of the fusion apparatus itself.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CPLX1HumanAtaxia  ISOCplx1 (Mus musculus) RGD 
Cplx1RatAtaxia  ISOCplx1 (Mus musculus) RGD 
Cplx1MouseAtaxia  IMP  RGD 
CPLX1Humanvisual epilepsy  ISOCplx1 (Mus musculus) RGD 
Cplx1Ratvisual epilepsy  ISOCplx1 (Mus musculus) RGD 
Cplx1Mousevisual epilepsy  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cplx1  (complexin 1)

Genes (Mus musculus)
Cplx1  (complexin 1)

Genes (Homo sapiens)
CPLX1  (complexin 1)

Objects referenced in this article
Gene CPLX2 complexin 2 Homo sapiens
Gene Cplx2 complexin 2 Mus musculus
Gene Cplx2 complexin 2 Rattus norvegicus

Additional Information