RGD Reference Report - Analyses of quantitative trait loci contributing to alcohol preference in HAD1/LAD1 and HAD2/LAD2 rats. - Rat Genome Database

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Analyses of quantitative trait loci contributing to alcohol preference in HAD1/LAD1 and HAD2/LAD2 rats.

Authors: Carr, LG  Habegger, K  Spence, J  Ritchotte, A  Liu, L  Lumeng, L  Li, TK  Foroud, T 
Citation: Carr LG, etal., Alcohol Clin Exp Res 2003 Nov;27(11):1710-7.
RGD ID: 731212
Pubmed: PMID:14634485   (View Abstract at PubMed)
DOI: DOI:10.1097/01.ALC.0000097161.51093.71   (Journal Full-text)

BACKGROUND: The high-alcohol-drinking (HAD1/HAD2) and low-alcohol-drinking (LAD1/LAD2) rat lines, derived from the N/NIH rat, were developed by using a within-family selection and rotational breeding design for alcohol preference and alcohol consumption. Previously, a 20-cM genome screen identified quantitative trait loci (QTLs) on chromosomes 5, 10, 12, and 16 by using F2 progeny from HAD1 and LAD1 animals. METHODS: A total of 459 F2 HAD1 x LAD1 animals had been previously genotyped, and 428 HAD2 x LAD2 F2 animals were genotyped for microsatellite markers within the identified QTL regions. Linkage analyses were performed with the program QTL Express, a recently developed Web-based interface that implements a least-squares method. RESULTS: The linkage peaks previously identified in the HAD1 x LAD1 genome scan relied on one or two markers. Placement of additional markers in and around the QTL regions provided further support for each of the QTLs. Two of the QTLs on chromosomes 10 and 16 were confirmed in the replicate line; these QTLs exhibited linkage in both the HAD1/LAD1 and HAD2/LAD2 studies. CONCLUSIONS: This study demonstrated the importance of confirmation of QTLs in a replicate line, as well as the complexity of the genetic contribution to alcohol preference. Assessing these QTL regions in the inbred HAD/LAD animals will further facilitate characterization of these regions.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Alc10Ratalcohol use disorder  IDA  RGD 
Alc11Ratalcohol use disorder  IDA  RGD 
Alc12Ratalcohol use disorder  IDA  RGD 
Alc13Ratalcohol use disorder  IDA  RGD 
Alc9Ratalcohol use disorder  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Alc10Ratalcohol preference  QTM  RGD 
Alc11Ratalcohol preference  QTM  RGD 
Alc12Ratalcohol preference  QTM  RGD 
Alc13Ratalcohol preference  QTM  RGD 
Alc9Ratalcohol preference  QTM  RGD 
Objects Annotated

QTLs
Alc10  (Alcohol consumption QTL 10)
Alc11  (Alcohol consumption QTL 11)
Alc12  (Alcohol consumption QTL 12)
Alc13  (Alcohol consumption QTL 13)
Alc9  (Alcohol consumption QTL 9)

Strains
Iusm:HAD1  (high-alcohol-drinking)
Iusm:HAD2  (high-alcohol-drinking)
Iusm:LAD1  (low-alcohol-drinking)
Iusm:LAD2  (low-alcohol-drinking)

Objects referenced in this article
QTL Alc4 Alcohol consumption QTL 4 Rattus norvegicus
QTL Alc5 Alcohol consumption QTL 5 Rattus norvegicus
QTL Alc6 Alcohol consumption QTL 6 Rattus norvegicus
QTL Alc7 Alcohol consumption QTL 7 Rattus norvegicus
QTL Alc8 Alcohol consumption QTL 8 Rattus norvegicus

Additional Information