RGD Reference Report - Cloning and expression of a cocaine-sensitive rat dopamine transporter. - Rat Genome Database

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Cloning and expression of a cocaine-sensitive rat dopamine transporter.

Authors: Kilty, JE  Lorang, D  Amara, SG 
Citation: Kilty JE, etal., Science 1991 Oct 25;254(5031):578-9.
RGD ID: 730214
Pubmed: PMID:1948035   (View Abstract at PubMed)

The action of dopamine and other monoamine neurotransmitters at synapses is terminated predominantly by high-affinity reuptake into presynaptic terminals by specific sodium-dependent neurotransmitter transport proteins. A complementary DNA encoding a rat dopamine transporter has been isolated that exhibits high sequence similarity with the previously cloned norepinephrine and gamma-aminobutyric acid transporters. Transient expression of the complementary DNA in HeLa cells confirms the cocaine sensitivity of this transporter.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc6a3Ratdopamine:sodium symporter activity enablesIDA PMID:1948035UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Slc6a3  (solute carrier family 6 member 3)


Additional Information