RGD Reference Report - RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. - Rat Genome Database

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RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements.

Authors: Yu, VC  Delsert, C  Andersen, B  Holloway, JM  Devary, OV  Naar, AM  Kim, SY  Boutin, JM  Glass, CK  Rosenfeld, MG 
Citation: Yu VC, etal., Cell 1991 Dec 20;67(6):1251-66.
RGD ID: 729677
Pubmed: PMID:1662118   (View Abstract at PubMed)

The retinoic acid receptor (RAR) requires coregulators to bind effectively to response elements in target genes. A strategy of sequential screening of expression libraries with a retinoic acid response element and RAR identified a cDNA encoding a coregulator highly related to RXR alpha. This protein, termed RXR beta, forms heterodimers with RAR, preferentially increasing its DNA binding and transcriptional activity on promoters containing retinoic acid, but not thyroid hormone or vitamin D, response elements. Remarkably, RXR beta also heterodimerizes with the thyroid hormone and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. RXR alpha also forms heterodimers with these receptors. These observations suggest that retinoid X receptors meet the criteria for biochemically characterized cellular coregulators and serve to selectively target the high affinity binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate DNA response elements.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RxrbRatnuclear receptor-mediated signaling pathway  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
RxrbRatnuclear receptor activity  IDA  RGD 
RxrbRatnuclear retinoic acid receptor binding  IDA  RGD 
RxrbRatnuclear thyroid hormone receptor binding  IDA  RGD 
RxrbRatnuclear vitamin D receptor binding  IDA  RGD 
RxrbRatprotein-containing complex binding  IDA heterodimerizationRGD 

Objects Annotated

Genes (Rattus norvegicus)
Rxrb  (retinoid X receptor beta)


Additional Information