RGD Reference Report - Molecular cloning of a member of a third class of Shaker-family K+ channel genes in mammals. - Rat Genome Database

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Molecular cloning of a member of a third class of Shaker-family K+ channel genes in mammals.

Authors: McCormack, T  Vega-Saenz de Miera, EC  Rudy, B 
Citation: McCormack T, etal., Proc Natl Acad Sci U S A 1990 Jul;87(13):5227-31.
RGD ID: 729382
Pubmed: PMID:2367536   (View Abstract at PubMed)
PMCID: PMC54295   (View Article at PubMed Central)

We report the cloning of RKShIIIA, a cDNA encoding a K+ channel sequence expressed in rat brain. This cDNA encodes K+ channel subunits that express in Xenopus oocytes a slow, 4-aminopyridine- and tetraethylammonium-sensitive, delayed rectifier-type K+ channel activated by large membrane depolarizations. This gene belongs to the Shaker (Sh) family of K+ channel genes, since the predicted protein has the same overall structure and shows significant homology to other members of this family. However, RKShIIIA cannot be assigned to either of the two known classes of Sh-family genes in mammals based on sequence analysis. Notable features of the RKShIIIA protein product include a probable cytoplasmic loop rich in prolines and a stretch very homologous to the Drosophila Shaw protein, both near the amino terminus.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnc2Ratpotassium ion transport involved_inIDA PMID:2367536UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnc2Ratdelayed rectifier potassium channel activity enablesIDA PMID:2367536UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Kcnc2  (potassium voltage-gated channel subfamily C member 2)


Additional Information