RGD Reference Report - Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia. - Rat Genome Database

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Cloning of a mammalian elk potassium channel gene and EAG mRNA distribution in rat sympathetic ganglia.

Authors: Shi, W  Wang, HS  Pan, Z  Wymore, RS  Cohen, IS  McKinnon, D  Dixon, JE 
Citation: Shi W, etal., J Physiol 1998 Sep 15;511 ( Pt 3):675-82.
RGD ID: 729210
Pubmed: PMID:9714851   (View Abstract at PubMed)
PMCID: PMC2231163   (View Article at PubMed Central)

1. Three new members of the EAG potassium channel gene family were identified in rat and the complete coding sequence of one of these genes (elk1) was determined by cDNA cloning. 2. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel. 3. The elk1 gene is expressed in sympathetic ganglia and is also expressed in sciatic nerve. 4. Six of the seven known EAG genes were found to be expressed in rat sympathetic ganglia, suggesting an important functional role for these channels in the sympathetic nervous system.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnh8Ratpotassium ion transport involved_inIDA PMID:9714851UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnh8Ratdelayed rectifier potassium channel activity enablesIDA PMID:9714851UniProt 
Kcnh8Ratvoltage-gated potassium channel activity  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kcnh8  (potassium voltage-gated channel subfamily H member 8)

Objects referenced in this article
Gene Kcnh3 potassium voltage-gated channel subfamily H member 3 Rattus norvegicus
Gene Kcnh5 potassium voltage-gated channel subfamily H member 5 Rattus norvegicus

Additional Information