RGD Reference Report - Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes. - Rat Genome Database

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Kv2.1/Kv9.3, a novel ATP-dependent delayed-rectifier K+ channel in oxygen-sensitive pulmonary artery myocytes.

Authors: Patel, AJ  Lazdunski, M  Honore, E 
Citation: Patel AJ, etal., EMBO J 1997 Nov 17;16(22):6615-25.
RGD ID: 729206
Pubmed: PMID:9362476   (View Abstract at PubMed)
PMCID: PMC1170266   (View Article at PubMed Central)
DOI: DOI:10.1093/emboj/16.22.6615   (Journal Full-text)

The molecular structure of oxygen-sensitive delayed-rectifier K+ channels which are involved in hypoxic pulmonary artery (PA) vasoconstriction has yet to be elucidated. To address this problem, we identified the Shab K+ channel Kv2.1 and a novel Shab-like subunit Kv9.3, in rat PA myocytes. Kv9.3 encodes an electrically silent subunit which associates with Kv2.1 and modulates its biophysical properties. The Kv2.1/9.3 heteromultimer, unlike Kv2.1, opens in the voltage range of the resting membrane potential of PA myocytes. Moreover, we demonstrate that the activity of Kv2.1/Kv9.3 is tightly controlled by internal ATP and is reversibly inhibited by hypoxia. In conclusion, we propose that metabolic regulation of the Kv2.1/Kv9.3 heteromultimer may play an important role in hypoxic PA vasoconstriction and in the possible development of PA hypertension.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnb1Ratdelayed rectifier potassium channel activity enablesIDA PMID:9362476UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Kcnb1  (potassium voltage-gated channel subfamily B member 1)

Objects referenced in this article
Gene Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 Rattus norvegicus

Additional Information