RGD Reference Report - Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system. - Rat Genome Database

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Alternative splicing contributes to K+ channel diversity in the mammalian central nervous system.

Authors: Luneau, CJ  Williams, JB  Marshall, J  Levitan, ES  Oliva, C  Smith, JS  Antanavage, J  Folander, K  Stein, RB  Swanson, R 
Citation: Luneau CJ, etal., Proc Natl Acad Sci U S A 1991 May 1;88(9):3932-6.
RGD ID: 728931
Pubmed: PMID:2023941   (View Abstract at PubMed)
PMCID: PMC51567   (View Article at PubMed Central)

In an attempt to define the molecular basis of the functional diversity of K+ channels, we have isolated overlapping rat brain cDNAs that encoded a neuronal delayed rectifier K+ channel, K,4, that is structurally related to the Drosophila Shaw protein. Unlike previously characterized mammalian K+ channel genes, which each contain a single protein-coding exon, K,4 arises from alternative exon usage at a locus that also encodes another mammalian Shaw homolog, NGK2. Thus, the enormous diversity of K+ channels in mammals can be generated not just through gene duplication and divergence but also through alternative splicing of RNA.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnc1Ratdelayed rectifier potassium channel activity enablesISSUniProtKB:Q95167PMID:2023941UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Kcnc1  (potassium voltage-gated channel subfamily C member 1)


Additional Information