RGD Reference Report - A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization. - Rat Genome Database

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A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization.

Authors: Hwang, PM  Glatt, CE  Bredt, DS  Yellen, G  Snyder, SH 
Citation: Hwang PM, etal., Neuron 1992 Mar;8(3):473-81.
RGD ID: 728916
Pubmed: PMID:1550672   (View Abstract at PubMed)

Using a cDNA library prepared from circumvallate papillae of rat tongue, we have identified, cloned, and sequenced a novel K+ channel, designated cdrk. The cdrk channel appears to be a member of the Shab subfamily, most closely resembling drk1. Electrophysiologic analysis of expressed cdrk channels reveals delayed rectifier properties similar to those of drk1 channels. Localizations of cdrk mRNA in rat brain and peripheral tissues, assessed by in situ hybridization and Northern blot analysis, differ from any other reported K+ channels. In the brain cdrk mRNA is most concentrated in granule cells of the olfactory bulb and cerebellum. In peripheral tissues, mRNAs for cdrk and drk1 are reciprocally localized, indicating that the K+ channel properties contributed by mammalian Shab homologs may be important in a variety of excitable tissues.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Kcnb2Ratdelayed rectifier potassium channel activity enablesIDA PMID:1550672UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Kcnb2  (potassium voltage-gated channel subfamily B member 2)


Additional Information