RGD Reference Report - Rat inbred PD/cub strain as a model of dyslipidemia and insulin resistance. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Rat inbred PD/cub strain as a model of dyslipidemia and insulin resistance.

Authors: Sedova, L  Kazdova, L  Seda, O  Krenova, D  Kren, V 
Citation: Sedova L, etal., Folia Biol (Praha) 2000;46(3):99-106.
RGD ID: 728088
Pubmed: PMID:10925780   (View Abstract at PubMed)

Genome scan and metabolic profile of the PD/Cub rat inbred strain in comparison with SHR and BN strains is presented. The PD/Cub strain has been bred by brother sister mating for more than 60 generations since 1969. Its highly inbred status has been confirmed by PCR genotyping with more than 170 microsatellite markers. No case of residual heterozygosity has been recorded. Accordingly, the values obtained by the analysis of metabolic phenotypes are homogeneous with low variance. The PD/Cub strain has significantly higher triglyceride levels and epididymal fat weight as compared to both SHR and BN strains. The PD strain also displays the lowest incorporation of 14C-U glucose into the epididymal adipose tissue. The data on glucose metabolism clearly indicate that the PD/Cub strain is insulin resistant. Genetic homogeneity and reproducibility of experimental results qualify the PD/Cub rats as an animal model for analysis of the syndrome X.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SHR/OlaIpcvRathyperglycemia MODEL: spontaneousIAGP  RGD 
PD/CubRatMetabolic Syndrome MODEL: spontaneousIAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PD/CubRatdecreased kidney weight  IAGP compared to SHR/Ola and BN/CubRGD 
PD/CubRatincreased circulating free fatty acids level  IAGP compared to BN/CubRGD 
SHR/OlaIpcvRatincreased circulating free fatty acids level  IAGP compared to BN/CubRGD 
PD/CubRatincreased circulating glucose level  IAGP compared to BN/CubRGD 
SHR/OlaIpcvRatincreased circulating glucose level  IAGP compared to BN/CubRGD 
PD/CubRatincreased circulating insulin level  IAGP compared to BN/CubRGD 
SHR/OlaIpcvRatincreased circulating insulin level  IAGP compared to BN/CubRGD 
PD/CubRatincreased circulating triglyceride level  IAGP compared to SHR/OlaIpcv and BN/CubRGD 
SHR/OlaIpcvRatincreased circulating triglyceride level  IAGP compared to BN/CubRGD 
PD/CubRatincreased epididymal fat pad weight  IAGP compared to SHR/OlaIpcv and BN/CubRGD 
SHR/OlaIpcvRatincreased kidney weight  IAGP compared to BN/CubRGD 
PD/CubRatincreased liver weight  IAGP compared to BN/CubRGD 
SHR/OlaIpcvRatincreased liver weight  IAGP compared to BN/CubRGD 
PD/CubRatincreased systemic arterial blood pressure  IAGP compared to BN/CubRGD 
SHR/OlaIpcvRatincreased systemic arterial blood pressure  IAGP compared to PD/Cub and BN/CubRGD 
Objects Annotated

Strains
PD/Cub  (polydactylous)
SHR/OlaIpcv  (NA)

Objects referenced in this article
Strain SHR/Ola null Rattus norvegicus

Additional Information