RGD Reference Report - AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast.

Authors: Kirchhausen, T  Davis, AC  Frucht, S  Greco, BO  Payne, GS  Tubb, B 
Citation: Kirchhausen T, etal., J Biol Chem 1991 Jun 15;266(17):11153-7.
RGD ID: 727584
Pubmed: PMID:2040623   (View Abstract at PubMed)

AP17 and AP19 are the smallest polypeptide chain components of AP-2 and AP-1, the clathrin-associated protein complexes found in coated structures of the plasma membrane and Golgi apparatus of mammalian cells. cDNA clones representing the entire coding sequence of AP17 and AP19 were isolated from rat and mouse brain cDNA libraries, respectively. Determination of their nucleotide sequence predicts proteins of 142 and 158 amino acids with Mr 17,018 and 18,733. A sequence comparison of rat brain AP17 with mouse brain AP19 demonstrates that the small chains are highly related. A computer search for other related proteins has uncovered in yeast a previously unknown gene whose DNA sequence encodes a protein homologous to the small chain of AP complexes. The yeast sequence predicts Yap17p, a protein with 147 amino acids and a Mr of 17,373 that is slightly more related to the mammalian AP17 chain than to its AP19 counterpart.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Ap2s1RatAP-2 adaptor complex part_ofIDA PMID:2040623MGI 

Objects Annotated

Genes (Rattus norvegicus)
Ap2s1  (adaptor related protein complex 2 subunit sigma 1)

Objects referenced in this article
Gene Ap1s1 adaptor protein complex AP-1, sigma 1 Mus musculus

Additional Information