RGD Reference Report - Disordered food intake and obesity in rats lacking cholecystokinin A receptors. - Rat Genome Database

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Disordered food intake and obesity in rats lacking cholecystokinin A receptors.

Authors: Moran, TH  Katz, LF  Plata-Salaman, CR  Schwartz, GJ 
Citation: Moran TH, etal., Am J Physiol. 1998 Mar;274(3 Pt 2):R618-25.
RGD ID: 7257724
Pubmed: PMID:9530226   (View Abstract at PubMed)

Otsuka Long-Evans Tokushima Fatty (OLETF) rats develop obesity, hyperglycemia, and non-insulin-dependent diabetes mellitus and do not express cholecystokinin A (CCK-A) receptors, the receptor subtype mediating the satiety actions of CCK. In short-term feeding tests, male OLETF rats were completely resistant to exogenous CCK, and their response to bombesin was attenuated. Comparisons of liquid meal consumption in OLETF and control Long-Evans Tokushima (LETO) rats demonstrated that 1) OLETF rats had greater intakes during 30-min scheduled daytime meals and significantly larger and fewer spontaneous night-time meals and 2) although the initial rates of licking were the same, OLETF rats maintained the initial rate longer and the rate at which their licking declined was slower. In 24-h solid food access tests, OLETF rats consumed significantly more pellets than LETO controls, and this increase was attributable to significant increases in meal size. Together, these data are consistent with the interpretation that the lack of CCK-A receptors in OLETF rats results in a satiety deficit leading to increases in meal size, overall hyperphagia, and obesity.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCKARHumanobesity  ISOCckar (Rattus norvegicus)DNA:deletionRGD 
CckarRatobesity  IAGP DNA:deletionRGD 
CckarMouseobesity  ISOCckar (Rattus norvegicus)DNA:deletionRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CckarRatpolyphagia  IAGP  RGD 
Objects Annotated

Genes (Rattus norvegicus)
Cckar  (cholecystokinin A receptor)

Genes (Mus musculus)
Cckar  (cholecystokinin A receptor)

Genes (Homo sapiens)
CCKAR  (cholecystokinin A receptor)


Additional Information