RGD Reference Report - Endothelial cell damage induces a blood-alveolus barrier breakdown in the development of radiation-induced lung injury. - Rat Genome Database

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Endothelial cell damage induces a blood-alveolus barrier breakdown in the development of radiation-induced lung injury.

Authors: Qiu, J  Li, J  He, TC 
Citation: Qiu J, etal., Asia Pac J Clin Oncol. 2011 Dec;7(4):392-8. doi: 10.1111/j.1743-7563.2011.01461.x.
RGD ID: 7257525
Pubmed: PMID:22151990   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1743-7563.2011.01461.x   (Journal Full-text)

AIM: To investigate the role of endothelial cell damage in radiation-induced lung injury. METHODS: A total of 60 male Sprague-Dawley rats were irradiated to the right hemithorax with a single dose of 0, 7.0 or 14.4 Gy. Serial studies were performed before and at 1, 7, 30 and 90 days after radiation, respectively. Pathological studies were carried out to detect changes in the lung after irradiation. Western blot studies were conducted to detect the expression of CD34 and of CD105 and vascular endothelial growth factor (VEGF). RESULTS: Compared to controls, the irradiated rat lung showed a dose-dependent and time-dependent decrease in the expression of CD34. The level of CD105 was significantly reduced by irradiation except at 90 days after radiation. The expression of VEGF increased 1 day after radiation, and then decreased from day 30 onwards, to be lower than the control group at 90 days. Pulmonary fibrosis was observed at 90 days after 14.4 Gy exposure; however, most of these phenomena were not observed in the 7.0 Gy group. CONCLUSION: These results support the notion that endothelial cells play an important role in radiation-induced lung injury, and may be critical to breakdown of the blood-alveolus barrier and microcirculation dysfunction related to radiation-induced inflammation and fibrosis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ENGHumanExperimental Radiation Injuries  ISOEng (Rattus norvegicus)protein:decreased expression:lung (rat)RGD 
EngRatExperimental Radiation Injuries  IEP protein:decreased expression:lung (rat)RGD 
EngMouseExperimental Radiation Injuries  ISOEng (Rattus norvegicus)protein:decreased expression:lung (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Eng  (endoglin)

Genes (Mus musculus)
Eng  (endoglin)

Genes (Homo sapiens)
ENG  (endoglin)


Additional Information