RGD Reference Report - Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3. - Rat Genome Database

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Quantitative trait loci with opposing blood pressure effects demonstrating epistasis on Dahl rat chromosome 3.

Authors: Palijan, A  Dutil, J  Deng, AY 
Citation: Palijan A, etal., Physiol Genomics 2003 Sep 29;15(1):1-8.
RGD ID: 724791
Pubmed: PMID:14517349   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00084.2003   (Journal Full-text)

Our previous linkage studies indicated that there might be a blood pressure (BP) quantitative trait locus (QTL) on chromosome 3 (Chr 3) contrasting between the Dahl salt-sensitive (S) strain and the Lewis (LEW) strain. To prove and then to narrow down the segment containing this QTL, five congenic strains have been generated by replacing various segments of the S rats with the homologous segments of the LEW rats. They are designated as S.L1, S.L2, S.L3, S.L4, and S.L5, respectively. S.L2, S.L3, S.L4, and S.L5 are substrains of S.L1, i.e., they contain substitutions of smaller sections within the large fragment defined by S.L1. The construction of these congenic strains was facilitated by a genome-wide marker screening process. BPs of the rats were measured by telemetry. S.L2 and S.L3 shared a fragment of Chr 3 in common and both showed a BP-lowering effect, indicating the existence of "-BP" QTL alleles from LEW compared with S. In contrast, S.L4 involves a section with no overlap with either S.L2 or S.L3, and S.L4 showed a BP significantly higher than that of S rats, indicating the presence of "+BP" QTL alleles from LEW compared with S. Interestingly, the combined effect of the -BP QTL and +BP QTL alleles was "-" in S.L1, implying that the "-" QTL is epistatic to "+" QTL.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp151Rathypertension  IAGP  RGD 
Bp152Rathypertension  IAGP  RGD 
SS.LEW-(D3Chm64-D3Rat17)/AydRathypertension inducedIAGPcontrolled sodium content diet RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp151Ratabnormal systemic arterial blood pressure  IAGP  RGD 
SS.LEW-(D3Rat52-D3Chm63)/AydRatdecreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D3Rat52-D3Rat130)/AydRatdecreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D3Rat52-D3Rat17)/AydRatdecreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D3Rat52-D3Chm63)/AydRatdecreased systemic arterial diastolic blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D3Rat52-D3Rat130)/AydRatdecreased systemic arterial diastolic blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D3Rat52-D3Rat17)/AydRatdecreased systemic arterial diastolic blood pressure inducedIAGPcontrolled sodium content diet RGD 
SS.LEW-(D3Rat52-D3Chm63)/AydRatdecreased systemic arterial systolic blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D3Rat52-D3Rat130)/AydRatdecreased systemic arterial systolic blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D3Rat52-D3Rat17)/AydRatdecreased systemic arterial systolic blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
SS.LEW-(D3Chm64-D3Rat17)/AydRatincreased mean systemic arterial blood pressure inducedIAGPcontrolled sodium content dietcompared to SS/JrRGD 
Bp152Ratincreased systemic arterial blood pressure  IAGP  RGD 
SS.LEW-(D3Chm64-D3Rat17)/AydRatincreased systemic arterial diastolic blood pressure inducedIAGPcontrolled sodium content diet RGD 
SS.LEW-(D3Chm64-D3Rat17)/AydRatincreased systemic arterial systolic blood pressure inducedIAGPcontrolled sodium content diet RGD 
SS.LEW-(D3Mco21-D3Rat17)/AydRatsalt-sensitive hypertension inducedIAGPcontrolled sodium content diet RGD 

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Objects Annotated

QTLs
Bp151  (Blood pressure QTL 151)
Bp152  (Blood pressure QTL 152)

Objects referenced in this article
Marker D3Chm66 D3Chm66 Rattus norvegicus
Marker D3Chm30 D3Chm30 Rattus norvegicus
Marker D3Chm61 D3Chm61 Rattus norvegicus
Marker D3Chm32 D3Chm32 Rattus norvegicus
Marker D3Chm2 D3Chm2 Rattus norvegicus
Marker D3Chm11 D3Chm11 Rattus norvegicus
Marker D3Chm10 D3Chm10 Rattus norvegicus
Marker D3Chm42 D3Chm42 Rattus norvegicus
Marker D3Chm58 D3Chm58 Rattus norvegicus
Marker D3Chm76 D3Chm76 Rattus norvegicus
Marker D3Chm55 D3Chm55 Rattus norvegicus
Marker D3Chm12 D3Chm12 Rattus norvegicus
Marker D3Chm40 D3Chm40 Rattus norvegicus
Marker D3Chm29 D3Chm29 Rattus norvegicus
Marker D3Chm68 D3Chm68 Rattus norvegicus
Marker D3Chm62 D3Chm62 Rattus norvegicus
Marker D3Chm39 D3Chm39 Rattus norvegicus
Marker D3Chm34 D3Chm34 Rattus norvegicus
Marker D3Chm15 D3Chm15 Rattus norvegicus
Marker D3Chm25 D3Chm25 Rattus norvegicus
Marker D3Chm51 D3Chm51 Rattus norvegicus
Marker D3Chm78 D3Chm78 Rattus norvegicus
Marker D3Chm64 D3Chm64 Rattus norvegicus
Marker D3Chm3 D3Chm3 Rattus norvegicus
Marker D3Chm80 D3Chm80 Rattus norvegicus
Marker D3Chm8 D3Chm8 Rattus norvegicus
Marker D3Chm26 D3Chm26 Rattus norvegicus
Marker D3Chm22 D3Chm22 Rattus norvegicus
Marker D3Chm43 D3Chm43 Rattus norvegicus
Marker D3Chm57 D3Chm57 Rattus norvegicus
Marker D3Chm37 D3Chm37 Rattus norvegicus
Marker D3Chm41 D3Chm41 Rattus norvegicus
Marker D3Chm7 D3Chm7 Rattus norvegicus
Marker D3Chm72 D3Chm72 Rattus norvegicus
Marker D3Chm36 D3Chm36 Rattus norvegicus
Marker D3Chm65 D3Chm65 Rattus norvegicus
Marker D3Chm79 D3Chm79 Rattus norvegicus
Marker D3Chm54 D3Chm54 Rattus norvegicus
Marker D3Chm63 D3Chm63 Rattus norvegicus
Marker D3Chm49 D3Chm49 Rattus norvegicus
Marker D3Chm60 D3Chm60 Rattus norvegicus
Marker D3Chm50 D3Chm50 Rattus norvegicus
Marker D3Chm6 D3Chm6 Rattus norvegicus
QTL Bw181 Body weght QTL 181 Rattus norvegicus
QTL Kidm37 Kidney mass QTL 37 Rattus norvegicus

Additional Information