RGD Reference Report - Characterization of the fawn-hooded rat as a model for hemostatic studies. - Rat Genome Database

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Characterization of the fawn-hooded rat as a model for hemostatic studies.

Authors: Raymond, SL  Dodds, WJ 
Citation: Raymond SL and Dodds WJ, Thromb Diath Haemorrh 1975 Apr 30;33(2):361-9.
RGD ID: 724730
Pubmed: PMID:1169825   (View Abstract at PubMed)

A large colony of fawn-hooded (FH) rats, comprising five original families and six generations of their progeny, was developed for genetic and comparative studies of their bleeding tendency. The characteristics of the bleeding diathesis in these rats are similar to those originally reported in related rats by Tschopp and Zucker. FH rats have normal clot retraction, ADP-induced platelet aggregation and platelet ADP; variable aggregation with collagen; minimal aggregation with adrenaline and cobra venom factor; and reduced platelet ATP, ATP/ADP ratio, serotonin content and -14C-serotonin release. In comparison to age- and sex-matched Wistar rats, FH rats have significantly prolonged partial thromboplastin time, shortened Russell's viper venom time and increased factor X and XI levels. Other coagulation screening tests and specific assays for fibrinogen, plasminogen and factors VII, VIII and IX were normal. Some age- and sex-related differences in coagulation and other parameters were observed within each rat strain. Plasma proteins, glycoproteins and ceruloplasmin (copper oxidase activity) showed no abnormalities, nor did initial studies of immunoglobulins and complement. However, FH rats have significantly lower glucose and higher cholesterol levels than comparable Wistar rats.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FHRatdecreased circulating glucose level  IAGP compared to WRGD 
FHRatdecreased platelet serotonin level  IAGP  RGD 
FHRatincreased circulating cholesterol level  IAGP compared to WRGD 
FHRatincreased circulating factor X level  IAGP compared to WRGD 
FHRatincreased circulating factor XI level  IAGP compared to WRGD 
FHRatincreased partial thromboplastin time  IAGP compared to WRGD 
Objects Annotated

Strains
FH  (NA)

Objects referenced in this article
Strain SD-GEPR-9 null Rattus norvegicus

Additional Information