RGD Reference Report - Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats. - Rat Genome Database

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Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats.

Authors: Liu, J  Zhou, F  Li, GY  Wang, L  Li, HX  Bai, GY  Guan, RL  Xu, YD  Gao, ZZ  Tian, WJ  Xin, ZC 
Citation: Liu J, etal., Int J Mol Sci. 2013 May 21;14(5):10661-73. doi: 10.3390/ijms140510661.
RGD ID: 7244246
Pubmed: PMID:23698784   (View Abstract at PubMed)
PMCID: PMC3676859   (View Article at PubMed Central)
DOI: DOI:10.3390/ijms140510661   (Journal Full-text)

To investigate the therapeutic effect of different doses of low energy shock wave therapy (LESWT) on the erectile dysfunction (ED) in streptozotocin (STZ) induced diabetic rats. SD rats (n = 75) were randomly divided into 5 groups (normal control, diabetic control, 3 different dose LESWT treated diabetic groups). Diabetic rats were induced by intra-peritoneal injection of STZ (60 mg/kg) and rats with fasting blood glucose >/= 300 mg/dL were selected as diabetic models. Twelve weeks later, different doses of LESWT (100, 200 and 300 shocks each time) treatment on penises were used to treat ED (7.33 MPa, 2 shocks/s) three times a week for two weeks. The erectile function was evaluated by intracavernous pressure (ICP) after 1 week washout period. Then the penises were harvested for histological study. The results showed LESWT could significantly improve the erectile function of diabetic rats, increase smooth muscle and endothelial contents, up-regulate the expression of alpha-SMA, vWF, nNOS and VEGF, and down- regulate the expression of RAGE in corpus cavernosum. The therapeutic effect might relate to treatment dose positively, and the maximal therapeutic effect was noted in the LESWT300 group. Consequently, 300 shocks each time might be the ideal LESWT dose for diabetic ED treatment.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AGERHumanimpotence treatmentISOAger (Rattus norvegicus)associated with Diabetes Mellitus and Experimental RGD 
AgerRatimpotence treatmentIDA associated with Diabetes Mellitus and Experimental RGD 
AgerMouseimpotence treatmentISOAger (Rattus norvegicus)associated with Diabetes Mellitus and Experimental RGD 
NOS1Humanimpotence treatmentISONos1 (Rattus norvegicus)associated with Diabetes Mellitus and ExperimentalRGD 
Nos1Ratimpotence treatmentIDA associated with Diabetes Mellitus and ExperimentalRGD 
Nos1Mouseimpotence treatmentISONos1 (Rattus norvegicus)associated with Diabetes Mellitus and ExperimentalRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ager  (advanced glycosylation end product-specific receptor)
Nos1  (nitric oxide synthase 1)

Genes (Mus musculus)
Ager  (advanced glycosylation end product-specific receptor)
Nos1  (nitric oxide synthase 1, neuronal)

Genes (Homo sapiens)
AGER  (advanced glycosylation end-product specific receptor)
NOS1  (nitric oxide synthase 1)


Additional Information