RGD Reference Report - Genetic risk for recurrent urinary tract infections in humans: a systematic review. - Rat Genome Database

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Genetic risk for recurrent urinary tract infections in humans: a systematic review.

Authors: Zaffanello, M  Malerba, G  Cataldi, L  Antoniazzi, F  Franchini, M  Monti, E  Fanos, V 
Citation: Zaffanello M, etal., J Biomed Biotechnol. 2010;2010:321082. doi: 10.1155/2010/321082. Epub 2010 Mar 30.
RGD ID: 7242733
Pubmed: PMID:20379347   (View Abstract at PubMed)
PMCID: PMC2847765   (View Article at PubMed Central)
DOI: DOI:10.1155/2010/321082   (Journal Full-text)

Urinary tract infections (UTIs) are a frequent cause of morbidity in children and adults and affect up to 10% of children; its recurrence rate is estimated at 30-40%. UTI may occur in up to 50% of all women in their lifetimes and frequently require medication. Recent advances have suggested that a deregulation of candidate genes in humans may predispose patients to recurrent UTI. The identification of a genetic component of UTI recurrences will make it possible to diagnose at-risk adults and to predict genetic recurrences in their offspring. Six out of 14 genes investigated in humans may be associated with susceptibility to recurrent UTI in humans. In particular, the HSPA1B, CXCR1 & 2, TLR2, TLR4, TGF-beta1 genes seem to be associated with an alteration of the host response to UTIs at various levels.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HSPA1BHumanurinary tract infection  IAGP DNA: SNP: :g.1267A>GRGD 
Hspa1bRaturinary tract infection  ISOHSPA1B (Homo sapiens)DNA: SNP: :g.1267A>GRGD 
Hspa1bMouseurinary tract infection  ISOHSPA1B (Homo sapiens)DNA: SNP: :g.1267A>GRGD 

Objects Annotated

Genes (Rattus norvegicus)
Hspa1b  (heat shock protein family A (Hsp70) member 1B)

Genes (Mus musculus)
Hspa1b  (heat shock protein 1B)

Genes (Homo sapiens)
HSPA1B  (heat shock protein family A (Hsp70) member 1B)


Additional Information