RGD Reference Report - Immunolocalization and mRNA expression of bone morphogenetic protein-6 in human clear cell renal carcinoma. - Rat Genome Database

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Immunolocalization and mRNA expression of bone morphogenetic protein-6 in human clear cell renal carcinoma.

Authors: Basic-Jukic, N  Radic-Antolic, M  Hudolin, T  Coric, M  Zadro, R  Pasini, J  Kastelan, Z  Kes, P 
Citation: Basic-Jukic N, etal., Kidney Blood Press Res. 2009;32(6):445-50. doi: 10.1159/000266479. Epub 2009 Dec 17.
RGD ID: 7242419
Pubmed: PMID:20016212   (View Abstract at PubMed)
DOI: DOI:10.1159/000266479   (Journal Full-text)

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta superfamily of proteins. Dysregulation of BMP signaling has been suggested in the carcinogenesis of different organs. We determined BMP-6 mRNA and protein expression in localized human clear cell renal carcinoma (CCRC), obtained from 20 patients who underwent nephrectomy, by the real-time polymerase chain reaction and immunohistochemistry. 15/20 patients exhibited higher BMP-6 mRNA expression in malignant than in healthy renal tissue relative to the PBGD expression (p < 0.05). Immunostaining intensity for BMP-6 in healthy renal tissue ranged from 0 to 2 (average 0.9), as well as in renal clear cell carcinoma (average 1.1). Seven of 20 (35%) healthy tissue samples failed to stain with BMP-6 antibody, compared to 2/20 (10%) tumor samples (p < 0.05). BMP-6 immunostaining was positive in 18/20 CCRC samples. Staining was localized in the cytoplasm and/or membrane of malignant cells. Malignant tissue had significantly higher BMP-6 mRNA expression than healthy tissue. There was no significant correlation between BMP-6 mRNA and protein expression with disease presentation, disease progression and patients' characteristics. Long-term follow-up of our patients is needed to determine the possible role of increased expression of BMP-6 in CCRC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BMP6Humanrenal cell carcinoma  IEP mRNA and protein:increased expression:kidneyRGD 
Bmp6Ratrenal cell carcinoma  ISOBMP6 (Homo sapiens)mRNA and protein:increased expression:kidneyRGD 
Bmp6Mouserenal cell carcinoma  ISOBMP6 (Homo sapiens)mRNA and protein:increased expression:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bmp6  (bone morphogenetic protein 6)

Genes (Mus musculus)
Bmp6  (bone morphogenetic protein 6)

Genes (Homo sapiens)
BMP6  (bone morphogenetic protein 6)


Additional Information