RGD Reference Report - BMP signaling in rats with TNBS-induced colitis following BMP7 therapy. - Rat Genome Database

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BMP signaling in rats with TNBS-induced colitis following BMP7 therapy.

Authors: Maric, I  Kucic, N  Turk Wensveen, T  Smoljan, I  Grahovac, B  Zoricic Cvek, S  Celic, T  Bobinac, D  Vukicevic, S 
Citation: Maric I, etal., Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1151-62. doi: 10.1152/ajpgi.00244.2011. Epub 2012 Feb 23.
RGD ID: 7242194
Pubmed: PMID:22361727   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpgi.00244.2011   (Journal Full-text)

Beyond stimulating bone formation, bone morphogenetic proteins (BMPs) are important in development, inflammation, and malignancy of the gut. We have previously shown that BMP7 has a regenerative, anti-inflammatory, and antiproliferative effect on experimental inflammatory bowel disease (IBD) in rats. To further investigate the BMP signaling pathway we monitored the effect of BMP7 therapy on the BMP signaling components in the rat colon during different stages of experimentally induced colitis by 2,4,6-trinitrobenzene sulfonic acid (TNBS). The results showed a significantly decreased BMP7 expression in the acute phase, followed by a significantly increased BMP2 and decreased BMP6 expression during the chronic phase of colitis. BMP7 therapy influenced the expression of several BMPs with the most prominent effect on downregulation of BMP2 and upregulation of BMP4 in the chronic phase of colitis. Importantly, connective tissue growth factor and noggin expression were elevated in the acute stage and significantly decreased upon BMP7 therapy. BMP receptor I expression was unchanged, whereas BMP receptor II was decreased at day 2 and increased at days 14 and 30 of TNBS inflammation. However, an opposite pattern of expression following BMP7 therapy has been observed. BMP7 increased the expression of BR-Smad including Smad3 and Smad4. Inhibitory Smads were increased in colitis and significantly decreased following BMP7 therapy at later stages of the disease. We suggest that BMP signaling was altered during TNBS-induced colitis and was recovered with BMP7 administration, suggesting that IBD is a reversible process.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BMP6Humancolitis  ISOBmp6 (Rattus norvegicus) RGD 
Bmp6Ratcolitis  IEP  RGD 
Bmp6Mousecolitis  ISOBmp6 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bmp6  (bone morphogenetic protein 6)

Genes (Mus musculus)
Bmp6  (bone morphogenetic protein 6)

Genes (Homo sapiens)
BMP6  (bone morphogenetic protein 6)


Additional Information