RGD Reference Report - BMP-6 and BMPR-1a are up-regulated in the growth plate of the fractured tibia. - Rat Genome Database

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BMP-6 and BMPR-1a are up-regulated in the growth plate of the fractured tibia.

Authors: Fischerauer, EE  Manninger, M  Seles, M  Janezic, G  Pichler, K  Ebner, B  Weinberg, AM 
Citation: Fischerauer EE, etal., J Orthop Res. 2013 Mar;31(3):357-63. doi: 10.1002/jor.22238. Epub 2012 Oct 23.
RGD ID: 7242189
Pubmed: PMID:23097200   (View Abstract at PubMed)
DOI: DOI:10.1002/jor.22238   (Journal Full-text)

Bone overgrowth is a known phenomenon occurring after fracture of growing long bones with possible long-term physical consequences for affected children. Here, the physeal expression of bone morphogenetic proteins (BMPs) was investigated in a fracture-animal model to test the hypothesis that a diaphyseal fracture stimulates the physeal expression of these known key regulators of bone formation, thus stimulating bone overgrowth. Sprague-Dawley rats (male, 4 weeks old), were subjected to a unilateral mid-diaphyseal tibial fracture. Kinetic expression of physeal BMP-2, -4, -6, -7, and BMP receptor-1a (BMPR-1a) was analyzed in a monthly period by quantitative real time-polymerase chain reaction and immunohistochemistry. On Days 1, 3, 10, and 14 post-fracture, no changes in physeal BMPs gene-expression were detected. Twenty-nine days post-fracture, when the fracture was consolidated, physeal expression of BMP-6 and BMPR-1a was significantly upregulated in the growth plate of the fractured and contra-lateral intact bone compared to control (p<0.005). This study demonstrates a late role of BMP-6 and BMPR-1a in fracture-induced physeal growth alterations and furthermore, may have discovered the existence of a regulatory "cross-talk" mechanism between the lower limbs whose function could be to limit leg-length-discrepancies following the breakage of growing bones.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BMP6HumanTibial Fractures  ISOBmp6 (Rattus norvegicus) RGD 
Bmp6RatTibial Fractures  IEP  RGD 
Bmp6MouseTibial Fractures  ISOBmp6 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bmp6  (bone morphogenetic protein 6)

Genes (Mus musculus)
Bmp6  (bone morphogenetic protein 6)

Genes (Homo sapiens)
BMP6  (bone morphogenetic protein 6)


Additional Information