RGD Reference Report - Association of TLR2 gene Arg753Gln polymorphism with urinary tract infection in children. - Rat Genome Database

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Association of TLR2 gene Arg753Gln polymorphism with urinary tract infection in children.

Authors: Tabel, Y  Berdeli, A  Mir, S 
Citation: Tabel Y, etal., Int J Immunogenet. 2007 Dec;34(6):399-405.
RGD ID: 7240561
Pubmed: PMID:18001294   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1744-313X.2007.00709.x   (Journal Full-text)

The aim of this study is to investigate Arg753Gln allele polymorphisms of toll-like receptor-2 (TLR2) gene distribution, allele frequency in urinary tract infection (UTI) and genotype-phenotype association of TLR2 gene in children with UTI. The polymorphism was investigated in 124 children with UTI (22 boys and 102 girls; mean age 5.81 +/- 3.47 years) with direct DNA sequencing-based method. TLR2 gene Arg753Gln allele frequency was higher in the patient group when compared with control group (OR 3.14, 95%CI 1.53-6.44, P < 0.001). The frequency of the Arg753Gln allele was significantly higher in gram-positive group than in gram-negative group (OR 7.64, 95%CI 2.80-20.81, P < 0.001). The frequency of UTI was found significantly higher in the Arg753Gln allele carriers of TLR2 gene than the non-carriers (OR 4.94, 95%CI 1.09-22.33, P < 0.05). Similarly, the incidence of asymptomatic UTI was also found significantly higher in the group carrying Arg753Gln allele (OR 3.73, 95%Cl 1.54-9.04, P < 0.05). As a result, we suggest that TLR2 gene could be the predisposing factor for urinary tract infection. Additionally, we observed that subjects carrying the TLR2 Arg753Gln allele had higher risk of urinary tract infection with gram-positive pathogens, history of more than two attacks of UTI and asymptomatic UTI.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TLR2Humanurinary tract infection susceptibilityIAGP DNA:polymorphism: :p.R753Q (human)RGD 
Tlr2Raturinary tract infection susceptibilityISOTLR2 (Homo sapiens)DNA:polymorphism: :p.R753Q (human)RGD 
Tlr2Mouseurinary tract infection susceptibilityISOTLR2 (Homo sapiens)DNA:polymorphism: :p.R753Q (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr2  (toll-like receptor 2)

Genes (Mus musculus)
Tlr2  (toll-like receptor 2)

Genes (Homo sapiens)
TLR2  (toll like receptor 2)


Additional Information