RGD Reference Report - The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. - Rat Genome Database

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The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.

Authors: Abdelmagid, N  Bereczky-Veress, B  Guerreiro-Cacais, AO  Bergman, P  Luhr, KM  Bergstrom, T  Skoldenberg, B  Piehl, F  Olsson, T  Diez, M 
Citation: Abdelmagid N, etal., PLoS Pathog. 2012;8(6):e1002753. doi: 10.1371/journal.ppat.1002753. Epub 2012 Jun 28.
RGD ID: 7240516
Pubmed: (View Article at PubMed) PMID:22761571
DOI: Full-text: DOI:10.1371/journal.ppat.1002753

Herpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide linkage scan in an intercross between the susceptible DA and the resistant PVG rat. We found one major quantitative trait locus (QTL), Hse1, on rat chromosome 4 (confidence interval 24.3-31 Mb; LOD score 29.5) governing disease susceptibility. Fine mapping of Hse1 using recombinants, haplotype mapping and sequencing, as well as expression analysis of all genes in the interval identified the calcitonin receptor gene (Calcr) as the main candidate, which also is supported by functional studies. Thus, using unbiased genetic approach variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent HSE development.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

Genes (Rattus norvegicus)
Calca  (calcitonin-related polypeptide alpha)
Calcr  (calcitonin receptor)

Genes (Mus musculus)
Calca  (calcitonin/calcitonin-related polypeptide, alpha)
Calcr  (calcitonin receptor)

Genes (Homo sapiens)
CALCA  (calcitonin related polypeptide alpha)
CALCR  (calcitonin receptor)

QTLs
Bw143  (Body weight QTL 143)
Bw144  (Body weight QTL 144)
Bw145  (Body weight QTL 145)
Vie1  (Viral induced encephalitis QTL 1)
Vie2  (Viral induced encephalitis QTL 2)
Vie3  (Viral induced encephalitis QTL 3)
Vie4  (Viral induced encephalitis QTL 4)
Vie5  (Viral induced encephalitis QTL 5)

Objects referenced in this article
Marker D4Kini3 D4Kini3 Rattus norvegicus
Marker D4Kini4 D4Kini4 Rattus norvegicus
Marker D4Kini5 D4Kini5 Rattus norvegicus
Marker D4Kini6 D4Kini6 Rattus norvegicus
Marker D4Kini7 D4Kini7 Rattus norvegicus
Marker D4Kini8 D4Kini8 Rattus norvegicus
Marker D4Kini9 D4Kini9 Rattus norvegicus
Marker D4Kini10 D4Kini10 Rattus norvegicus
Marker D4Kini11 D4Kini11 Rattus norvegicus
Marker D4Kini12 D4Kini12 Rattus norvegicus
Marker D4Kini13 D4Kini13 Rattus norvegicus
Marker D4Kini14 D4Kini14 Rattus norvegicus
Marker D4Kini15 D4Kini15 Rattus norvegicus
Marker D4Kini16 D4Kini16 Rattus norvegicus
Marker D4Kini17 D4Kini17 Rattus norvegicus
Marker D4Kini18 D4Kini18 Rattus norvegicus
Strain DA.PVG.1AV1-(D4Kini3-D4Mgh14)/Kini null Rattus norvegicus
Strain DA.PVG.1AV1-(D4Kini3-D4Rat177)/Kini null Rattus norvegicus

Additional Information