RGD Reference Report - Association of Toll-like receptor 4 gene polymorphism and expression with urinary tract infection types in adults. - Rat Genome Database

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Association of Toll-like receptor 4 gene polymorphism and expression with urinary tract infection types in adults.

Authors: Yin, X  Hou, T  Liu, Y  Chen, J  Yao, Z  Ma, C  Yang, L  Wei, L 
Citation: Yin X, etal., PLoS One. 2010 Dec 3;5(12):e14223. doi: 10.1371/journal.pone.0014223.
RGD ID: 7207862
Pubmed: PMID:21151974   (View Abstract at PubMed)
PMCID: PMC2997054   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0014223   (Journal Full-text)

BACKGROUND: Innate immunity of which Toll-like receptor (TLR) 4 and CXCR1 are key elements plays a central role in the development of urinary tract infection (UTI). Although the relation between the genetics of TLR4 and CXCR1 and UTI is investigated partly, the polymorphisms and expression of TLR4 and CXCR1 in different types of UTI in adults are not extremely clear. METHODOLOGY/PRINCIPAL FINDINGS: This study investigates the presence of TLR4 A (896) G and CXCR1 G (2608) C polymorphisms in 129 UTI patients using RFLP-PCR. Gene and allelic prevalence were compared with 248 healthy controls. Flow cytometry was used to detect TLR4 and CXCR1 expression in the monocytes of UTI patients and healthy controls. TLR4 (896) AG genotype and TLR4 (896) G allele had higher prevalence in UTI (especially in acute cystitis and urethritis) patients, whereas CXCR1 (2608) GC genotype and CXCR1 (2608) C allele had lower prevalence in UTI patients than controls. TLR4 expression was significantly lower in chronic UTI patients than in acute pyelonephritis or healthy controls. CXCR1 expression was similar in both controls and patients. TLR4 expression in chronic UTI patients after astragalus treatment was higher than pre-treatment. CONCLUSIONS: The results indicate the relationship between the carrier status of TLR4 (896) G alleles and the development of UTI, especially acute cystitis and urethritis, in adults. TLR4 expression levels are correlated with chronic UTI.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CXCR1Humanurinary tract infection  IAGP  RGD 
Cxcr1Raturinary tract infection  ISOCXCR1 (Homo sapiens) RGD 
Cxcr1Mouseurinary tract infection  ISOCXCR1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cxcr1  (C-X-C motif chemokine receptor 1)

Genes (Mus musculus)
Cxcr1  (C-X-C motif chemokine receptor 1)

Genes (Homo sapiens)
CXCR1  (C-X-C motif chemokine receptor 1)


Additional Information