RGD Reference Report - Decreased endothelial size and connexin expression in rat caudal arteries during hypertension. - Rat Genome Database

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Decreased endothelial size and connexin expression in rat caudal arteries during hypertension.

Authors: Rummery, NM  McKenzie, KU  Whitworth, JA  Hill, CE 
Citation: Rummery NM, etal., J Hypertens. 2002 Feb;20(2):247-53.
RGD ID: 7207848
Pubmed: PMID:11821709   (View Abstract at PubMed)

OBJECTIVES: Hypertension is accompanied by endothelial dysfunction. The present study has investigated endothelial cell morphology and connexin expression in the caudal artery of the rat during the development of hypertension. METHODS: A significant increase in systolic blood pressure was detected from 9 weeks of age in spontaneously hypertensive male rats (SHR) compared to normotensive Wistar-Kyoto (WKY) rats, reaching a maximum by 11-12 weeks of age. Immunohistochemistry was used to quantify cell size and expression of connexins (Cxs) 37, 40 and 43 in the endothelium of prehypertensive (3-week-old) and hypertensive (12-week-old) rats. RESULTS: At 12 weeks, the size of endothelial cells and the expression of all three Cxs per endothelial cell were significantly less in SHR than WKY rats. At 3 weeks, there was no significant difference in cell size nor in the expression of Cxs 37 or 43; however, expression of Cx40 was significantly lower in SHR than in WKY rats. Between 3 and 12 weeks in WKY rats, there was no change in endothelial cell size, nor in the expression of Cxs 37, 40 and 43. In SHR, both cell size and Cx expression per endothelial cell were significantly decreased during the same developmental period, with a significant decrease in the density of Cx40 plaques. CONCLUSION: The development of hypertension in the SHR is accompanied by significant decreases in endothelial cell size and expression of Cx40, which may contribute to the endothelial dysfunction present in hypertension.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GJA5Humanhypertension  ISOGja5 (Rattus norvegicus)protein:decreased expression:artery endothelium RGD 
Gja5Rathypertension  IEP protein:decreased expression:artery endothelium RGD 
Gja5Mousehypertension  ISOGja5 (Rattus norvegicus)protein:decreased expression:artery endothelium RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gja5  (gap junction protein, alpha 5)

Genes (Mus musculus)
Gja5  (gap junction protein, alpha 5)

Genes (Homo sapiens)
GJA5  (gap junction protein alpha 5)


Additional Information