RGD Reference Report - Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats. - Rat Genome Database

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Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats.

Authors: Okuno, S  Watanabe, TK  Ono, T  Yamasaki, Y  Goto, Y  Miyao, H  Asai, T  Kanemoto, N  Oga, K  Mizoguchi-Miyakita, A  Takagi, T  Takahashi, E  Nakamura, Y  Tanigami, A 
Citation: Okuno S, etal., Genomics 1999 Dec 15;62(3):350-5.
RGD ID: 70852
Pubmed: PMID:10644432   (View Abstract at PubMed)
DOI: DOI:10.1006/geno.1999.6018   (Journal Full-text)

Altered lipid metabolism is closely associated with diabetes in humans, although predisposing genetic factors that affect hyperlipidemia have not yet been clarified. Our previously established OLETF strain is an obese rat model of type II diabetes, exhibiting hypertriglycemia as well as hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. To identify genetic factors responsible for dyslipidemic phenotypes in OLETF rats, we performed a whole-genome scan using 293 male (OLETF x BN) x OLETF backcross rats. Our analysis identified two significant quantitative trait loci (QTLs), on rat chromosomes 1 and 8, that are related to fasting triglyceride levels. The chromosome 1 QTL colocalized with Dmo1 (diabetes mellitus, OLETF type 1), a locus previously shown to associate strongly with both fat levels and body weight. The other significant QTL localizes to the chromosome 8 marker D8Mit2, in a region where several apo-lipoprotein genes are clustered.

Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

Stl8  (Serum triglyceride level QTL 8)
Stl9  (Serum triglyceride level QTL 9)

BN  (BN)
OLETF  (Otsuka Long-Evans Tokushima fatty)

Additional Information