RGD Reference Report - Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals.

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Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals.
Authors:	Tom Dieck, S Sanmarti-Vila, L Langnaese, K Richter, K Kindler, S Soyke, A Wex, H Smalla, KH Kampf, U Franzer, JT Stumm, M Garner, CC Gundelfinger, ED
Citation:	tom Dieck S, etal., J Cell Biol 1998 Jul 27;142(2):499-509.
RGD ID:	69780
Pubmed:	PMID:9679147 (View Abstract at PubMed)
PMCID:	PMC2133055 (View Article at PubMed Central)
The molecular architecture of the cytomatrix of presynaptic nerve terminals is poorly understood. Here we show that Bassoon, a novel protein of >400,000 Mr, is a new component of the presynaptic cytoskeleton. The murine bassoon gene maps to chromosome 9F. A comparison with the corresponding rat cDNA identified 10 exons within its protein-coding region. The Bassoon protein is predicted to contain two double-zinc fingers, several coiled-coil domains, and a stretch of polyglutamines (24 and 11 residues in rat and mouse, respectively). In some human proteins, e.g., Huntingtin, abnormal amplification of such poly-glutamine regions causes late-onset neurodegeneration. Bassoon is highly enriched in synaptic protein preparations. In cultured hippocampal neurons, Bassoon colocalizes with the synaptic vesicle protein synaptophysin and Piccolo, a presynaptic cytomatrix component. At the ultrastructural level, Bassoon is detected in axon terminals of hippocampal neurons where it is highly concentrated in the vicinity of the active zone. Immunogold labeling of synaptosomes revealed that Bassoon is associated with material interspersed between clear synaptic vesicles, and biochemical studies suggest a tight association with cytoskeletal structures. These data indicate that Bassoon is a strong candidate to be involved in cytomatrix organization at the site of neurotransmitter release.

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Biological Process

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Bsn	Rat	cytoskeleton organization		NAS			RGD

Cellular Component

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
Bsn	Rat	cytoskeleton of presynaptic active zone	located_in	IDA		PMID:9679147	SynGO-UCL
Bsn	Rat	glutamatergic synapse	is_active_in	IDA		PMID:9679147	SynGO
Bsn	Rat	hippocampal mossy fiber to CA3 synapse	is_active_in	IDA		PMID:9679147	SynGO
Bsn	Rat	presynaptic active zone cytoplasmic component	is_active_in	IDA		PMID:9679147	SynGO

Objects Annotated

Genes (Rattus norvegicus)

Bsn (bassoon (presynaptic cytomatrix protein))

Objects referenced in this article

Gene	Bsn	bassoon	Mus musculus

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Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals.