RGD Reference Report - High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains. - Rat Genome Database

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High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains.

Authors: Cicila, GT  Garrett, MR  Lee, SJ  Liu, J  Dene, H  Rapp, JP 
Citation: Cicila GT, etal., Genomics 2001 Feb 15;72(1):51-60.
RGD ID: 69711
Pubmed: (View Article at PubMed) PMID:11247666
DOI: Full-text: DOI:10.1006/geno.2000.6442

It was previously shown using Dahl salt-sensitive (S) and salt-resistant (R) rats that a blood pressure quantitative trait locus (QTL) was present on rat chromosome 7. In the present work, this QTL was localized to a region less than 0.54 cM in size on the linkage map using a series of congenic strains. This region was contained in a single yeast artificial chromosome that was 220 kb long. This small segment still contained the primary candidate locus Cyp11b1 (11beta-hydroxylase), but the adjacent candidate genes Cyp11b2 (aldosterone synthase) and Cyp11b3 were ruled out. It is concluded that 11beta-hydroxylase, through its known genetic variants altering the production of 18-hydroxy-11-deoxy corticosterone, is very likely to account for the blood pressure QTL on chromosome 7 in the Dahl rat model of hypertension. This QTL accounts for about 23 mm Hg under the condition of 2% NaCl diet for 24 days. Copyright 2001 Academic Press.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype

Objects Annotated

QTLs
Bp169  (Blood pressure QTL 169)
Bp61  (Blood pressure QTL 61)

Objects referenced in this article
QTL Bpq6_m blood pressure QTL 6 (mouse) Mus musculus
Gene Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 Rattus norvegicus
Strain SS.SR-(Cyp11b1)/Jr null Rattus norvegicus
Strain SS.SR-(D7Mco7-D7Rat81)/Jr null Rattus norvegicus
Strain SS.SR-(D7Rat16-D7Rat176)/Jr null Rattus norvegicus

Additional Information