RGD Reference Report - Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats. - Rat Genome Database

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Blood pressure and survival of a chromosome 7 congenic strain bred from Dahl rats.

Authors: Cicila, GT  Dukhanina, OI  Kurtz, TW  Walder, R  Garrett, MR  Dene, H  Rapp, JP 
Citation: Cicila GT, etal., Mamm Genome 1997 Dec;8(12):896-902.
RGD ID: 69710
Pubmed: PMID:9383281   (View Abstract at PubMed)

11 beta-hydroxylase (Cyp11b1) mutations were previously linked to altered steroid biosynthesis and blood pressure in Dahl salt-resistant (R) and Dahl salt-sensitive (S) rats. In the present work, interval mapping identified a putative blood pressure quantitative trait locus (QTL) near Cyp11b1 in an F1(SxR)xS population (LOD = 2.0). Congenic rats (Designated S.R-Cyp11b) were constructed by introgressing the R-rat Cyp11b1 allele into the S strain. S.R-Cyp11b rats had significantly lower blood pressure and heart weight compared with S rats, proving the existence of a blood pressure QTL on Chromosome (Chr) 7 despite the fact that QTL linkage analysis of blood pressure never achieved stringent statistical criteria for significance. To test the effects of the introgressed region on blood pressure and survival, S.R.-Cyp11b and S rats were maintained on a 4% NaCl diet until they died or became moribund. Analysis of variance (ANOVA) indicated significant strain differences in blood pressure and days survived (P < 0.0001 for both) as well as gender differences in days survived (P = 0.0003). Kaplan-Meier survival analysis also found significant strain (P < 0.0001) and gender (P = 0.007) differences in days survived. However, when the effects of blood pressure were removed, significant strain differences in survival essentially disappeared. This suggests that the increased survival of S.R-Cyp11b rats was largely due to their decreased blood pressure and thus strongly corroborates the existence of a blood pressure QTL on Chr 7 near or at Cyp11b1.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cm1RatCardiomegaly  IAGP  RGD 
Cm1Rathypertension  IAGP  RGD 
SS/JrRathypertension MODEL: inducedIAGPcontrolled sodium content dietcompared to SS.SR-(Cyp11b1)/Jr strainRGD 

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Mammalian Phenotype


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Objects Annotated

QTLs
Bp61  (Blood pressure QTL 61)
Cm1  (Cardiac mass QTL 1)

Strains
SR/Jr  (Salt Resistant)
SS.SR-(Cyp11b1)/Jr  (NA)
SS/Jr  (Salt Sensitive)


Additional Information