RGD Reference Report - Mapping of quantitative trait loci for body weight on chromosomes 1 and 4 in the rat. - Rat Genome Database

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Mapping of quantitative trait loci for body weight on chromosomes 1 and 4 in the rat.

Authors: Kovacs, P  Kloting, I 
Citation: Kovacs P and Kloting I, Biochem Mol Biol Int 1998 Feb;44(2):399-405.
RGD ID: 69707
Pubmed: PMID:9530522   (View Abstract at PubMed)

Quantitative trait loci (QTLs) affecting body weight were investigated in the backcross population derived from diabetic BB/OK and spontaneously hypertensive rat (SHR). The F1 hybrids were backcrossed onto BB/OK rats, and QTL analysis was performed with the resulting backcross population on chromosomes 1, 3, 4, 10, 13 and 18. According to the stringent threshold for a lod score of 3.0, markers on chromosomes 1 and 4 were found to be linked with body weight. The QTL with a peak lod score (3.3) on chromosome 1 for a male population was located within the region flanked by loci Igf2 and D1Mgh12. On chromosome 4, linkage between the body weight and the region around the Npy locus was observed (lod score 3.1). The existence of the QTL on chromosome 4 affecting body weight was confirmed by congenic BB.LL rats, carrying chromosomal region of SHR (D4Mit6-Npy-Spr) on the genetic background of the BB/OK rat.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw22RatBody Weight Changes  IDA  RGD 
Bw39Ratobesity  IDA  RGD 
Bw40Ratobesity  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw40Ratincreased body weight  IAGP  RGD 
Bw22Ratobese  QTM  RGD 
Objects Annotated

Bw22  (Body weight QTL 22)
Bw39  (Body weight QTL 39)
Bw40  (Body weight QTL 40)

BB.SHR-(D4Mit6-Spr)/K  (NA)
BB/OK  (BioBreeding rat)
SHR/Mol  (NA)

Additional Information