RGD Reference Report - Identification of a quantitative trait locus influencing plasma insulin levels after 70% pancreatectomy using the OLETF rat. - Rat Genome Database

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Identification of a quantitative trait locus influencing plasma insulin levels after 70% pancreatectomy using the OLETF rat.

Authors: Moralejo, DH  Ogino, T  Zhu, M  Toide, K  Wei, S  Wei, K  Yamada, T  Mizuno, A  Matsumoto, K  Shima, K 
Citation: Moralejo DH, etal., J Vet Med Sci 1998 Oct;60(10):1157-60.
RGD ID: 69703
Pubmed: PMID:9819774   (View Abstract at PubMed)

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type non-insulin-dependent diabetes mellitus (NIDDM) in humans. The OLETF rat has poor capacity for proliferation of pancreatic beta-cells after partial pancreatectomy, which may be the critical pathogenetic event in NIDDM development. The poor pancreatic beta-cell proliferation in this model is characterized by reduction in beta-cell mass and decrease in insulin content in the remnant pancreas. Our investigation was designed to identify quantitative trait loci (QTLs) responsible for beta-cell mass and plasma insulin levels after partial pancreatectomy by performing a genome-wide scan in an F2 intercross obtained by mating the OLETF and the Fischer-344 (F344) rats. We have identified a suggestive QTL for the plasma insulin levels, near D20Mgh5 on rat chromosome 20, with a maximum lod score of 3.75 which accounts for 20% of the total variance, while no QTLs were detected for beta-cell mass. This chromosome 20 QTL, whose OLETF allele is associated with low plasma insulin levels through acting in an incompletely recessive manner, may affect insulin secretion itself rather than beta-cell proliferation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Insul2Rattype 2 diabetes mellitus  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Insul2Ratdecreased circulating insulin level  QTM  RGD 
Objects Annotated

QTLs
Insul2  (Insulin level QTL 2)

Strains
F344/NRrrc  (NA)
OLETF/Got  (Otsuka Long Evans Tokushima)


Additional Information