RGD Reference Report - Congenic strain confirms putative quantitative trait locus for body weight in the rat. - Rat Genome Database

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Congenic strain confirms putative quantitative trait locus for body weight in the rat.

Authors: Kovacs, P  Voigt, B  Kloting, I 
Citation: Kovacs P, etal., Mamm Genome 1998 Apr;9(4):294-6.
RGD ID: 69701
Pubmed: PMID:9530625   (View Abstract at PubMed)
DOI: DOI:10.1007/s003359900751   (Journal Full-text)

Quantitative trait loci (QTLs) affecting body weight were investigated in the backcross population derived from non-diabetic BB/OK and spontaneously hypertensive rat (SHR) strains. The F1 hybrids were backcrossed onto SHR rats, and QTL analysis was performed separately with the resulting backcross populations for each sex on Chromosomes (Chrs) 1, 3, 4, 10, 13, and 18. The body weight was determined at the age of 14 weeks, and the statistical analysis was performed with MAPMAKER/QTL 1.1b computer program. According to the stringent threshold for a lod score of 3.0, markers on Chr 1 were found to be linked with body weight. The QTL with a peak lod score (5.1) on Chr 1 for a male population was located within markers Igf2 and D1Mgh12. In contrast, in the female population the body weight affecting QTL (lod = 5.7) on Chr 1 was located between the D1Mit3 and Lsn markers. The existence of QTLs on Chr 1 affecting body weight in the male population was confirmed by congenic BB.Sa rats, carrying chromosomal region of SHR (Sa-Igf2) on the genetic background of BB rat.

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Phenotype Annotations    

Mammalian Phenotype

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Strains with Phenominer Data Strains with phenominer dataStrains with phenominer data
BB/OK SHR/Mol BB.SHR-(Acsm3-Igf2)/K

Objects Annotated

Bw18  (Body weight QTL 18)
Bw20  (Body weight QTL 20)

BB.SHR-(Acsm3-Igf2)/K  (NA)
BB/OK  (BioBreeding rat)
SHR/Mol  (NA)

Additional Information